Necrotizing Scleritis, Conjunctivitis, and Other Pathologic Findings in the Left Eye and Brain of an Ebola Virus-Infected Rhesus Macaque (Macaca mulatta) With Apparent Recovery and a Delayed Time of Death

被引：22

作者：

Alves, Derron A. ^{[1
]}

Honko, Anna N. ^{[2
]}

Kortepeter, Mark G. ^{[3
]}

Sun, Mei ^{[4
]}

Johnson, Joshua C. ^{[2
]}

Lugo-Roman, Luis A. ^{[5
]}

Hensley, Lisa E. ^{[2
]}

机构：

[1] Def Hlth Agcy, Def Hlth Headquarters, Vet Serv, 7700 Arlington Blvd, Falls Church, VA 22042 USA

[2] NIAID, Integrated Res Facil, NIH, Ft Detrick, MD USA

[3] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA

[4] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA

[5] US Army, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 213卷 / 01期

关键词：

Ebola virus disease; Ebola virus; sequelae; macaque; rhesus; intramuscular; delayed death; eye; brain; HEMORRHAGIC-FEVER; ZAIRE-EBOLAVIRUS; CONGO; KIKWIT;

D O I：

10.1093/infdis/jiv357

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 3.5-year-old adult female rhesus macaque (Macaca mulatta) manifested swelling of the left upper eyelid and conjunctiva and a decline in clinical condition 18 days following intramuscular challenge with Ebola virus (EBOV; Kikwit-1995), after apparent clinical recovery. Histologic lesions with strong EBOV antigen staining were noted in the left eye (scleritis, conjunctivitis, and peri-optic neuritis), brain (choriomeningoencephalitis), stomach, proximal duodenum, and pancreas. Spleen, liver, and adrenal glands, common targets for acute infection, appeared histologically normal with no evidence of EBOV immunoreactivity. These findings may provide important insight for understanding sequelae seen in West African survivors of Ebola virus disease.

引用

页码：57 / 60

页数：4

共 15 条

[1]

[Anonymous], 2011, Guide for the care and use of laboratory animals

[2] Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: Clinical observations in 103 patients [J].

Bwaka, MA ;

Bonnet, MJ ;

Calain, P ;

Colebunders, R ;

De Roo, A ;

Guimard, Y ;

Katwiki, KR ;

Kibadi, K ;

Kipasa, MA ;

Kuvula, KJ ;

Mapanda, BB ;

Massamba, M ;

Mupapa, KD ;

Muyembe-Tamfum, JJ ;

Ndaberey, E ;

Peters, CJ ;

Rollin, PE ;

Van den Enden, E .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 :S1-S7

[3]

Firger J, SURVIVING EBOLA THOS

[4] OUTBREAK OF MARBURG VIRUS DISEASE IN JOHANNESBURG [J].

GEAR, JSS ;

CASSEL, GA ;

GEAR, AJ ;

TRAPPLER, B ;

CLAUSEN, L ;

MEYERS, AM ;

KEW, MC ;

BOTHWELL, TH ;

SHER, R ;

MILLER, GB ;

SCHNEIDER, J ;

KOORNHOF, HJ ;

GOMPERTS, ED ;

ISAACSON, M ;

GEAR, JHS .

BRITISH MEDICAL JOURNAL, 1975, 4 (5995) :489-493

[5] Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques - Evidence that dendritic cells are early and sustained targets of infection [J].

Geisbert, TW ;

Hensley, LE ;

Larsen, T ;

Young, HA ;

Reed, DS ;

Geisbert, JB ;

Scott, DP ;

Kagan, E ;

Jahrling, PB ;

Davis, KJ .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (06) :2347-2370

[6] Isolated case of Ebola hemorrhagic fever with mucormycosis complications, Kinshasa, Democratic Republic of the Congo [J].

Kalongi, Y ;

Mwanza, K ;

Tshisuaka, M ;

Lusiama, N ;

Ntando, E ;

Kanzake, L ;

Shieh, WJ ;

Zaki, SR ;

Lloyd, ES ;

Ksiazek, TG ;

Rollin, PE .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 :S15-S17

[7] Late ophthalmologic manifestations in survivors of the 1995 Ebola virus epidemic in Kikwit, Democratic Republic of the Congo [J].

Kibadi, K ;

Mupapa, K ;

Kuvula, K ;

Massamba, M ;

Ndaberey, D ;

Muyembe-Tamfum, JJ ;

Bwaka, MA ;

De Roo, A ;

Colebunders, R .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 :S13-S14

[8] Real-time Monitoring of Cardiovascular Function in Rhesus Macaques Infected With Zaire ebolavirus [J].

Kortepeter, Mark G. ;

Lawler, James V. ;

Honko, Anna ;

Bray, Mike ;

Johnson, Joshua C. ;

Purcell, Bret K. ;

Olinger, Gene G. ;

Rivard, Robert ;

Hepburn, Matthew J. ;

Hensley, Lisa E. .

JOURNAL OF INFECTIOUS DISEASES, 2011, 204 :S1000-S1010

[9] Basic Clinical and Laboratory Features of Filoviral Hemorrhagic Fever [J].

Kortepeter, Mark G. ;

Bausch, Daniel G. ;

Bray, Mike .

JOURNAL OF INFECTIOUS DISEASES, 2011, 204 :S810-S816

[10] Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus [J].

Larsen, Thomas ;

Stevens, Edward L. ;

Davis, Kelly J. ;

Geisbert, Joan B. ;

Daddario-DiCaprio, Kathleen M. ;

Jahrling, Peter B. ;

Hensley, Lisa E. ;

Geisbert, Thomas W. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 196 :S323-S328

← 1 2 →