RNA interference of HIV replication

被引：64

作者：

Martínez, MA ^{[1
]}

Clotet, B ^{[1
]}

Esté, JA ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Retrovirol Lab IrsiCaixa, Badalona 08916, Spain

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 12期

关键词：

D O I：

10.1016/S1471-4906(02)02328-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Double-stranded RNA-mediated interference (RNAi) induces sequence-specific post-transcriptional gene silencing and has emerged as a powerful tool to silence gene expression in multiple organisms. In mammalian cells, duplexes of 21 nucleoticle RNAs, known as short-interfering RNAs (siRNAs), efficiently inhibit gene expression. Recent research demonstrates the general use of siRNAs to specifically inhibit HIV-1 replication by targeting viral or cellular genes. Importantly, RNAi opens a new avenue for gene-based therapeutics.

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收藏

页码：559 / 561

页数：3

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