Hepatitis G virus in clotting factor concentrates

被引:3
作者
Alonso-Rubiano, E
Gerber, M
Friedman, P
Hodges, S
Leissinger, C
机构
[1] Tulane Univ, Sch Med, Hematol Oncol Sect, Dept Pediat Gastroenterol, New Orleans, LA 70112 USA
[2] Tulane Univ, Sch Med, Dept Pathol, New Orleans, LA 70112 USA
[3] Tulane Univ, Sch Med, Dept Hematol Oncol, New Orleans, LA 70112 USA
[4] Abbott Labs, Div Diagnost, Abbott Pk, IL 60064 USA
关键词
clotting factor concentrates; haemophilia; hepatitis G;
D O I
10.1046/j.1365-2516.2003.00706.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Blood-borne hepatitis is a well-known complication in patients with bleeding disorders. A recently discovered parentally transmitted virus, hepatitis G [GB virus C (GBV-C)] has an increased prevalence in patients with haemophilia. Clotting factor concentrates derived from pools of human plasma currently undergo viral inactivation techniques known to be effective against hepatitis B, C and HIV; however, the effectiveness of current purification and viral inactivation techniques against newly discovered viruses such as GBV-C is unknown. A total of 37 vials of clotting factor concentrates manufactured in the USA from 1981 to 1995 were tested for the presence of GBV-C virus. All samples that did not undergo a specific viral inactivation step were positive for GBV-C. Viral inactivation techniques that did not uniformly remove GBV-C included vapour heat treatment and dry heat treatments for less than 144 h. All samples treated by pasteurization, solvent detergent or dry heat for 144 h, were negative for the presence of GBV-C.
引用
收藏
页码:110 / 115
页数:6
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