Ethanol Lock Technique: Review of the Literature

被引：69

作者：

Maiefski, Melissa ^{[1
]}

Rupp, Mark E. ^{[3
]}

Hermsen, Elizabeth D. ^{[1
,2
,3
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Pharmaceut & Nutr Care, Nebraska Med Ctr, Omaha, NE 68198 USA

[2] Univ Nebraska Med Ctr, Dept Pharm Practice, Coll Pharm, Omaha, NE 68198 USA

[3] Univ Nebraska Med Ctr, Infect Dis Sect, Dept Internal Med, Omaha, NE 68198 USA

来源：

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY | 2009年 / 30卷 / 11期

关键词：

CATHETER-RELATED INFECTIONS; BLOOD-STREAM INFECTION; CENTRAL VENOUS CATHETERS; CRITICALLY-ILL PATIENTS; INTENSIVE-CARE PATIENTS; HEMODIALYSIS CATHETERS; INTRAVASCULAR DEVICES; MECHANICAL-PROPERTIES; BACTEREMIA; PREVENTION;

D O I：

10.1086/606162

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Central venous catheters (CVCs) are commonly used among adult and pediatric patients for administration of fluids, medications, and nutrition. Central line-associated (CLA) bloodstream infection (BSI) is a serious complication following CVC insertion. The aim of this review is to summarize available data regarding the ethanol lock technique, which is a proposed method for sterilizing the lumen of the catheter by instilling an ethanol solution and allowing it to dwell in the catheter for a certain amount of time. Studies on ethanol lock technique differ in ethanol concentrations, luminal dwell times, catheter types, inclusion of anticoagulants, use of systemic antibiotics, and use of the technique for prevention or for treatment of CLA BSI. In vitro studies demonstrate the efficacy of ethanol in the eradication of various pathogens. Definitive catheter integrity data are limited. Clinical trials report tolerable adverse events with ethanol locks, as well as encouraging results for prevention and treatment of CLA BSI.

引用

页码：1096 / 1108

页数：13

共 47 条

[1] Ethanol locking as a possible treatment for microbial contamination of long-term central venous catheters [J].

Ball, PA ;

Brokenshire, E ;

Parry, B ;

Merrie, A ;

Gillanders, L ;

McIlroy, K ;

Plank, L .

NUTRITION, 2003, 19 (06) :570-570

[2]

Beathard GA, 1999, J AM SOC NEPHROL, V10, P1045

[3]

Bell AL, 2006, CLIN NEPHROL, V65, P342

[4] Antibiotic lock technique: Review of the literature [J].

Bestul, MB ;

VandenBussche, HL .

PHARMACOTHERAPY, 2005, 25 (02) :211-227

[5] Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections [J].

Blot, SI ;

Depuydt, P ;

Annemans, L ;

Benoit, D ;

Hoste, E ;

de Waele, JJ ;

Decruyenaere, J ;

Vogelaers, D ;

Colardyn, F ;

Vandewoude, KH .

CLINICAL INFECTIOUS DISEASES, 2005, 41 (11) :1591-1598

[6] Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: Results from a prospective trial [J].

Broom, Jennifer ;

Woods, Marion ;

Allworth, Anthony ;

McCarthy, James ;

Faoagali, Joan ;

MacDonald, Sarah ;

Pithie, Alan .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2008, 40 (05) :399-406

[7] Treatment of Staphylococcus epidermidis central vascular catheter infection with 70% ethanol locks:: efficacy in a sheep model [J].

Chambers, Stephen T. ;

Pithie, Alan ;

Gallagher, Katrina ;

Liu, Tina ;

Charles, Christopher J. ;

Seaward, Lois .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 59 (04) :779-782

[8] The effects of prolonged ethanol exposure on the mechanical properties of polyurethane and silicone catheters used for intravascular access [J].

Crnich, CJ ;

Halfmann, JA ;

Crone, WC ;

Maki, DG .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2005, 26 (08) :708-714

[9] Ethanol-lock technique in the treatment of bloodstream infections in pediatric oncology patients with broviac catheter [J].

Dannenberg, C ;

Bierbach, U ;

Rothe, A ;

Beer, J ;

Körholz, D .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2003, 25 (08) :616-621

[10] Device-associated infections: A macroproblem that starts with microadherence [J].

Darouiche, RO .

CLINICAL INFECTIOUS DISEASES, 2001, 33 (09) :1567-1572

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