Characterization of smooth lipopolysaccharides and O polysaccharides of Brucella species by competition binding assays with monoclonal antibodies

被引：38

作者：

Weynants, V ^{[1
]}

Gilson, D ^{[1
]}

Cloeckaert, A ^{[1
]}

Tibor, A ^{[1
]}

Denoel, PA ^{[1
]}

Godfroid, F ^{[1
]}

Limet, JN ^{[1
]}

Letesson, JJ ^{[1
]}

机构：

[1] INST NATL RECH AGRON, CTR RECH TOURS, NOUZILLY, FRANCE

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 05期

关键词：

D O I：

10.1128/IAI.65.5.1939-1943.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previously, four epitope specificities on the O chain of Brucella species were reported: M, A, C, and C/Y. In this work, according to monoclonal antibody binding to smooth lipopolysaccharides of Yersinia enterocolitica O:9, Brucella abortus W99 (A-dominant strain), and B. melitensis Rev1 (M dominant strain), seven O-chain epitope specificities were defined: M, A, C (M > A), C (M = A), C/Y (M > A), C/Y (M = A) and C/Y (A > M). Competitive binding assays between these monoclonal antibodies suggested that these different epitopes are probably overlapping structures.

引用

页码：1939 / 1943

页数：5

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