Inhibition of HIV-1 nuclear import via Schiff base formation with arylene bis(methylketone) compounds

被引：21

作者：

Al-Abed, Y

Dubrovsky, L

Ruzsicska, B

Seepersaud, M

Bukrinsky, M

机构：

[1] N Shore LIJ Res Inst, Med Chem Lab, Manhasset, NY 11030 USA

[2] George Washington Univ, Dept Microbiol & Trop Med, Washington, DC 20037 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(02)00642-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Arylene bis(methylketone) compounds specifically block nuclear translocation of the HIV-1 pre-integration complex by forming Schiff-base adducts with contiguous lysines within nuclear localization signal. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：3117 / 3119

页数：3

共 15 条

[1]

HIV-1 infection requires a functional integrase NLS [J].

Bouyac-Bertoia, M ;

Dvorin, JD ;

Fouchier, RAM ;

Jenkins, Y ;

Meyer, BE ;

Wu, LI ;

Emerman, M ;

Malim, MH .

MOLECULAR CELL, 2001, 7 (05) :1025-1035

[2]

A NUCLEAR-LOCALIZATION SIGNAL WITHIN HIV-1 MATRIX PROTEIN THAT GOVERNS INFECTION OF NONDIVIDING CELLS [J].

BUKRINSKY, MI ;

HAGGERTY, S ;

DEMPSEY, MP ;

SHAROVA, N ;

ADZHUBEI, A ;

SPITZ, L ;

LEWIS, P ;

GOLDFARB, D ;

EMERMAN, M ;

STEVENSON, M .

NATURE, 1993, 365 (6447) :666-669

[3]

BUKRINSKY MI, 1999, FRONT BIOSCI, V4, P772

[4]

Combination therapy with zidovudine, didanosine and saquinavir [J].

Collier, AC ;

Coombs, RW ;

Schoenfeld, DA ;

Bassett, R ;

Baruch, A ;

Corey, L .

ANTIVIRAL RESEARCH, 1996, 29 (01) :99-99

[5]

Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine [J].

Collier, AC ;

Coombs, RW ;

Schoenfeld, DA ;

Bassett, RL ;

Timpone, J ;

Baruch, A ;

Jones, M ;

Facey, K ;

Whitacre, C ;

McAuliffe, VJ ;

Friedman, HM ;

Merigan, TC ;

Reichman, RC ;

Hooper, C ;

Corey, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (16) :1011-1017

[6]

NUCLEAR-LOCALIZATION SIGNAL OF HIV-1 AS A NOVEL TARGET FOR THERAPEUTIC INTERVENTION [J].

DUBROVSKY, L ;

ULRICH, P ;

NUOVO, GJ ;

MANOGUE, KR ;

CERAMI, A ;

BUKRINSKY, M .

MOLECULAR MEDICINE, 1995, 1 (02) :217-230

[7]

Small molecule inhibitor of HIV-1 nuclear import suppresses HIV-1 replication in human lymphoid tissue ex vivo: a potential addition to current anti-HIV drug repertoire [J].

Glushakova, S ;

Dubrovsky, L ;

Grivel, JC ;

Haffar, O ;

Bukrinsky, M .

ANTIVIRAL RESEARCH, 2000, 47 (02) :89-95

[8]

CNI-H0294, a nuclear importation inhibitor of the human immunodeficiency virus type 1 genome, abrogates virus replication in infected activated peripheral blood mononuclear cells [J].

Haffar, OK ;

Smithgall, MD ;

Popov, S ;

Ulrich, P ;

Bruce, AG ;

Nadler, SG ;

Cerami, A ;

Bukrinsky, MI .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (05) :1133-1138

[9]

Two nuclear localization signals in the HIV-1 matrix protein regulate nuclear import of the HIV-1 pre-integration complex [J].

Haffar, OK ;

Popov, S ;

Dubrovsky, L ;

Agostini, I ;

Tang, H ;

Pushkarsky, T ;

Nadler, SG ;

Bukrinsky, M .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 299 (02) :359-368

[10]

THE VPR PROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFLUENCES NUCLEAR-LOCALIZATION OF VIRAL NUCLEIC-ACIDS IN NONDIVIDING HOST-CELLS [J].

HEINZINGER, NK ;

BUKRINSKY, MI ;

HAGGERTY, SA ;

RAGLAND, AM ;

KEWALRAMANI, V ;

LEE, MA ;

GENDELMAN, HE ;

RATNER, L ;

STEVENSON, M ;

EMERMAN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (15) :7311-7315

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