Systemic infections and inflammation affect chronic neurodegeneration

被引：807

作者：

Perry, V. Hugh ^{[1
]}

Cunningham, Colm

Holmes, Clive

机构：

[1] Univ Southampton, Southampton Neurosci Grp, Sch Biol Sci, Southampton SO16 7PX, Hants, England

[2] Univ Southampton, Sch Med, Southampton SO16 7PX, Hants, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 02期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/nri2015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.

引用

页码：161 / 167

页数：8

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