Direct and remote constriction of membrane necks

被引：10

作者：

Bozic, Bojan ^{[1
]}

Guven, Jemal ^{[2
]}

Vazquez-Montejo, Pablo ^{[3
]}

Svetina, Sasa ^{[1
,4
]}

机构：

[1] Univ Ljubljana, Inst Biophys, Fac Med, SI-1000 Ljubljana, Slovenia

[2] Univ Nacl Autonoma Mexico, Inst Ciencias Nucl, Mexico City 04510, DF, Mexico

[3] Carnegie Mellon Univ, Dept Phys, Pittsburgh, PA 15213 USA

[4] Jozef Stefan Inst, SI-1000 Ljubljana, Slovenia

来源：

PHYSICAL REVIEW E | 2014年 / 89卷 / 05期

关键词：

PHOSPHOLIPID-VESICLES; SHAPE; ENDOCYTOSIS; FISSION; CURVATURE; YEAST; CELLS;

D O I：

10.1103/PhysRevE.89.052701

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 [等离子体物理]; 070301 [无机化学];

摘要：

The physical properties of membrane necks are relevant in vesiculation, a process that plays an essential role in cellular physiology. Because the neck's radius is, in general, finite, membrane scission and the consequent pinching off of the vesicle can only occur if it is narrowed to permit the necessary membrane topological reformation. Here we examine, in a simple single phase lipid vesicle, how external forces can promote neck constriction not only by direct compression at the neck but also, counterintuitively, by dilation at remote locations. These results provide a new perspective on the role played by actin polymerization in the process of endocytosis.

引用

页数：7

共 21 条

[1]

Distinct Roles for F-BAR Proteins Cdc15p and Bzz1p in Actin Polymerization at Sites of Endocytosis in Fission Yeast [J].