Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells

被引：12

作者：

Mai Duy Luu Trinh ^{[1
]}

Minh-Hiep Dinh

Ngo, Dai-Hung ^{[2
]}

Dang-Khoa Tran ^{[1
]}

Quoc-Tuan Tran ^{[1
]}

Vo, Thanh-Sang ^{[2
]}

Dai-Nghiep Ngo ^{[1
]}

机构：

[1] Vietnam Natl Univ Ho Chi Minh City, Univ Sci, Fac Biol, Dept Biochem, Ho Chi Minh City, Vietnam

[2] Pukyong Natl Univ, Specialized Grad Sch Sci & Technol Convergence, Dept Marinebio Convergence Sci, Pusan 608737, South Korea

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2014年 / 66卷

关键词：

Anti-inflammation; 4-Hydroxybenzyl-chitooligomers; Chang liver cells; iNOS; COX-2; NITRIC-OXIDE SYNTHASE; AMINOETHYL-CHITOOLIGOSACCHARIDES; CHITOSAN OLIGOSACCHARIDES; OXIDATIVE STRESS; INHIBIT; CYCLOOXYGENASE-2; EXPRESSION; PROTEIN;

D O I：

10.1016/j.ijbiomac.2014.01.064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The aim of this study was to investigate anti-inflammatory activity of 4-hydroxybenzyl-chitooligomers (HB-COS) in Chang liver cells stimulated by a cytokine mixture. It was revealed that HB-COS decreased the level of nitric oxide and prostaglandin E-2 (PGE(2)) production by diminishing the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without significant cytotoxicity. Moreover, HB-COS exerted inhibitory effects on the production of pro-inflammatory mediator (interleukin-6) in Chang liver cells. Notably, HB-COS exhibited anti-inflammatory activities via blocking degradation of inhibitory kappa B alpha (I kappa B-alpha), translocation of nuclear factor kappa B (NF-kappa B), and phosphorylation of mitogen-activated protein kinases (MAPKs) in a dose-dependent manner. Collectively, these findings indicated that HB-COS possessed potential anti-inflammatory effects in Chang liver cells, and could be a useful therapeutic agent for the treatment of hepatic inflammatory diseases. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

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