The evaluation of biologically important trace metals in liver, kidney and breast tissue

被引：45

作者：

Al-Ebraheem, A. ^{[1
]}

Farquharson, M. J. ^{[1
]}

Ryan, E. ^{[1
]}

机构：

[1] City Univ London, Dept Radiog, Inst Community & Hlth Sci, London EC1V 0HB, England

来源：

APPLIED RADIATION AND ISOTOPES | 2009年 / 67卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

Trace elements; Liver; Kidney; Breast; XRF; mu SRXRF; SYNCHROTRON XRF; ELEMENTS; COPPER; CARCINOMA; POTASSIUM; CANCER; ZINC;

D O I：

10.1016/j.apradiso.2008.06.018

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学];

摘要：

The levels of iron (Fe), copper (Cu), zinc (Zn) and potassium (K) have been measured in normal and malignant liver and kidney tissue using X-ray fluorescence. Zn was reduced in liver and kidney tumours by 63% and 26%, respectively. Fe, Cu and K were increased in kidney tumours by 150%, 8% and 90%, and reduced in liver tumours by 76%, 29% and 43%. A synchrotron microprobe was used to map calcium (Ca), Fe, Cu and Zn in breast tissue. The distributions were compared to reference images and higher concentrations of metals correlated with areas of cancer cells. The average increase of Ca, Fe, Cu and Zn concentrations in areas of malignancy were 70%, 43%, 53% and 87%. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：470 / 474

页数：5

共 16 条

[1]

X-ray fluorescence spectrometry: applications in trace elements studies in human tissues from patients with cirrhosis [J].

Carvalho, ML ;

Marques, AF .

X-RAY SPECTROMETRY, 2001, 30 (06) :397-402

[2]

CHVAPIL M, 1972, P SOC EXP BIOL MED, V140, P42

[3]

Trace elements distribution in renal cell carcinoma depending on stage of disease [J].

Dobrowolski, Z ;

Drewniak, T ;

Kwiatek, W ;

Jakubik, P .

EUROPEAN UROLOGY, 2002, 42 (05) :475-480

[4]

The localisation and micro-mapping of copper and other trace elements in breast tumours using a synchrotron micro-XRF system [J].

Farquharson, M. J. ;

Geraki, K. ;

Falkenberg, G. ;

Leek, R. ;

Harris, A. .

APPLIED RADIATION AND ISOTOPES, 2007, 65 (02) :183-188

[5]

A synchrotron XRF study on trace elements and potassium in breast tissue [J].

Geraki, K ;

Farquharson, MJ ;

Bradley, DA ;

Hugtenburg, RP .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2004, 213 :564-568

[6]

Concentrations of Fe, Cu and Zn in breast tissue: a synchrotron XRF study [J].

Geraki, K ;

Farquharson, MJ ;

Bradley, DA .

PHYSICS IN MEDICINE AND BIOLOGY, 2002, 47 (13) :2327-2339

[7]

Preliminary study on the distribution of selected elements in cancerous and non-cancerous kidney tissues [J].

Kwiatek, WM ;

Drewniak, T ;

Gajda, M ;

Galka, M ;

Hanson, AL ;

Cichocki, T .

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2002, 16 (03) :155-160

[8]

Investigation of trace elements in cancer kidney tissues by SRIXE and PIXE [J].

Kwiatek, WM ;

Drewniak, T ;

Lekka, M ;

Wajdowicz, A .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1996, 109 :284-288

[9]

Liaw KY, 1997, AM J GASTROENTEROL, V92, P2260

[10]

Maeda T, 2005, HEPATO-GASTROENTEROL, V52, P187

← 1 2 →