p75NTR is positively promiscuous: Novel partners and new insights

被引：259

作者：

Barker, PA ^{[1
]}

机构：

[1] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada

来源：

NEURON | 2004年 / 42卷 / 04期

关键词：

D O I：

10.1016/j.neuron.2004.04.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although identified almost 20 years ago, the precise physiological role of the p75 neurotrophin receptor (p75NTR) has remained elusive. Recent studies have revealed that p75NTR is a component of three distinct receptor platforms that bind different ligands and that, under differing circumstances, facilitate cell survival, cell death, or growth inhibition. These recent developments provide new insights into the functions of this enigmatic receptor.

引用

页码：529 / 533

页数：5

共 26 条

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