Induction of the early growth response 1 gene by Epstein-Barr virus lytic transactivator Zta

被引：57

作者：

Chang, Yao

Lee, Heng-Huan

Chen, Yu-Te

Lu, Jean

Wu, Shih-Yi

Chen, Chaio-Wei

Takada, Kenzo

Tsai, Ching-Hwa

机构：

[1] Natl Taiwan Univ, Coll Med, Grad Inst Microbiol, Taipei 10764, Taiwan

[2] Natl Hlth Res Inst, Div Clin Res, Tainan, Taiwan

[3] Hokkaido Univ, Inst Med Genet, Dept Tumor Virol, Sapporo, Hokkaido, Japan

来源：

JOURNAL OF VIROLOGY | 2006年 / 80卷 / 15期

关键词：

D O I：

10.1128/JVI.02608-05

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Early growth response 1 (Egr-1) is a cellular transcription factor involved in diverse biologic functions. Egr-1 has been associated with Epstein-Barr virus (EBV) infection, but it is still unknown whether any EBV protein regulates Egr-1 expression. In this study, we first showed that EBV reactivation is involved in upregulation of Egr-1 and that Egr-1 can be induced by Zta, an EBV lytic transactivator. Zta not only binds to the Egr-1 promoter but also activates the ERK signaling pathway to trigger binding of Elk-1 to the Egr-1 promoter. In addition, knockdown of Egr-1 significantly reduces the spontaneous expression of Zta and Rta in EBV-infected 293 cells, suggesting that a positive-feedback network involving Egr-1 is required for EBV reactivation. This study also implies that Zta has the potential to affect expression of certain genes through Egr-1.

引用

页码：7748 / 7755

页数：8

共 56 条

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