Ion-channels of cyclic template-assembled alamethicins that emulate the pore structure predicted by the barrel-stave model

被引：40

作者：

Matsubara, A

Asami, K

Akagi, A

Nishino, N

机构：

[1] KYOTO UNIV,INST CHEM RES,UJI,KYOTO 611,JAPAN

[2] KYUSHU INST TECHNOL,DEPT APPL CHEM,KITAKYUSHU,FUKUOKA 804,JAPAN

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 17期

关键词：

D O I：

10.1039/cc9960002069

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Single channel measurements of cyclic template-assembled synthetic peptides (TASP) AL(n)-cyclo2n [AL = Ac-UPUAUAQUVUGLUPVUUG-, U = alpha-aminoisobutyric acid; cyclo2n = cyclo(-Lys-Abz-)(n), Abz = m-aminobenzoic acid] in lipid bilayer membranes reveal that the lowest and the next lowest conductance states of the alamethicin ion-channel are made up of three and four parallel helices, respectively, as predicted by the barrel-stave model.

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页码：2069 / 2070

页数：2

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