Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

被引：853

作者：

Maji, Samir K. ^{[1
]}

Perrin, Marilyn H. ^{[2
]}

Sawaya, Michael R. ^{[3
]}

Jessberger, Sebastian ^{[4
]}

Vadodaria, Krishna ^{[4
]}

Rissman, Robert A. ^{[5
]}

Singru, Praful S. ^{[6
]}

Nilsson, K. Peter R. ^{[7
]}

Simon, Rozalyn ^{[7
]}

Schubert, David ^{[8
]}

Eisenberg, David ^{[3
]}

Rivier, Jean ^{[2
]}

Sawchenko, Paul ^{[2
]}

Vale, Wylie ^{[2
]}

Riek, Roland ^{[1
]}

机构：

[1] ETH, Phys Chem Lab, CH-8093 Zurich, Switzerland

[2] Salk Inst Biol Studies, Clayton Fdn Labs Peptide Biol, La Jolla, CA 92037 USA

[3] Univ Calif Los Angeles, Howard Hughes Med Inst, DOE Inst Genom & Prote, Los Angeles, CA 90095 USA

[4] ETH, Inst Cell Biol, Dept Biol, CH-8093 Zurich, Switzerland

[5] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[6] Tufts Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02111 USA

[7] Linkoping Univ, IFM, Dept Chem, SE-58183 Linkoping, Sweden

[8] Salk Inst Biol Studies, Cellular Neurobiol Lab, La Jolla, CA 92037 USA

来源：

SCIENCE | 2009年 / 325卷 / 5938期

基金：

美国国家科学基金会;

关键词：

MOLECULAR-ORGANIZATION; PROLACTIN GRANULES; PROTEIN; BIOGENESIS; GLYCOSAMINOGLYCANS; SYNUCLEIN; PATHWAYS; FIBRILS; HEPARIN; ATT-20;

D O I：

10.1126/science.1173155

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross-beta-sheet-rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.

引用

页码：328 / 332

页数：5

共 37 条

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