Condensed representation of DNA primary sequences

被引:101
作者
Randic, M [1 ]
机构
[1] Natl Inst Chem, Ljubljana 1001, Slovenia
来源
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES | 2000年 / 40卷 / 01期
关键词
D O I
10.1021/ci990084z
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
With rapid reporting of DNA sequences derived from automated DNA sequencing techniques, the problem of reviewing and ordering such information has become acute. We have introduced a condensed representation of primary sequences of DNA that offers an alternative method of registering DNA. The advantage of the condensed codes for DNA is that it not only offers fast, qualitative comparisons of DNA but also allows quantitative comparisons of DNA from different sources. The approach is outlined for a particular human beta globin sequence extract. Using the condensed representation of the primary DNA sequences, comparisons are made between primary sequences for Exon 1 of human beta globin and seven other beta globins.
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页码:50 / 56
页数:7
相关论文
共 17 条
[1]   TOWARD A GENERAL CALCULUS OF PHONEMIC DISTRIBUTION [J].
HARARY, F ;
PAPER, HH .
LANGUAGE, 1957, 33 (02) :143-169
[2]  
HUEN YK, 1995, VISUALIZING BIOL INF, P165
[3]   COMPARISON OF SEQUENCES AS A METHOD FOR EVALUATION OF THE MOLECULAR SIMILARITY [J].
JERMANBLAZIC, B ;
FABIC, I ;
RANDIC, M .
JOURNAL OF COMPUTATIONAL CHEMISTRY, 1986, 7 (02) :176-188
[4]   AN OVERVIEW OF SEQUENCE COMPARISON - TIME WARPS, STRING EDITS, AND MACROMOLECULES [J].
KRUSKAL, JB .
SIAM REVIEW, 1983, 25 (02) :201-237
[5]   Distributions of distances in information strings [J].
Kunz, M ;
Radl, Z .
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1998, 38 (03) :374-378
[6]  
NANDY A, 1994, CURR SCI INDIA, V66, P309
[7]  
Nandy A, 1996, CURR SCI INDIA, V70, P661
[8]   A GENERAL METHOD APPLICABLE TO SEARCH FOR SIMILARITIES IN AMINO ACID SEQUENCE OF 2 PROTEINS [J].
NEEDLEMAN, SB ;
WUNSCH, CD .
JOURNAL OF MOLECULAR BIOLOGY, 1970, 48 (03) :443-+
[9]  
NINIO J, 1995, VISUALIZING BIOL INF, P33
[10]   ON THE CHARACTERIZATION OF FULLERENES [J].
RANDIC, M .
FULLERENE SCIENCE AND TECHNOLOGY, 1994, 2 (04) :427-444