Heparin binding nanostructures to promote growth of blood vessels

被引:337
作者
Rajangam, Kanya
Behanna, Heather A.
Hui, Michael J.
Han, Xiaoqiang
Hulvat, James F.
Lomasney, Jon W.
Stupp, Samuel I. [1 ]
机构
[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
[2] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
[3] Northwestern Univ, Dept Pathol, Evanston, IL 60208 USA
[4] Northwestern Univ, Inst BioNanotechnol Med, Evanston, IL 60208 USA
[5] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA
[6] Northwestern Univ, Dept Med, Evanston, IL 60208 USA
关键词
D O I
10.1021/nl0613555
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Controlling new blood vessel formation is of interest in regenerative medicine and cancer treatment. Heparin, a biopolymer that binds to angiogenic growth factors, was used to nucleate the self-assembly of nanostructures from designed peptide amphiphile molecules. This process yields rigid nanofibers that display heparin chains to orient proteins for cell signaling. In vivo, the nanostructures stimulated extensive new blood vessel formation using nanogram amounts of growth-factor proteins that by themselves did not induce any detectable angiogenesis.
引用
收藏
页码:2086 / 2090
页数:5
相关论文
共 31 条
[1]   Materials science - Smart biomaterials [J].
Anderson, DG ;
Burdick, JA ;
Langer, R .
SCIENCE, 2004, 305 (5692) :1923-1924
[2]   Coassembly of amphiphiles with opposite peptide polarities into nanofibers [J].
Behanna, HA ;
Donners, JJJM ;
Gordon, AC ;
Stupp, SI .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (04) :1193-1200
[3]   Self-assembling peptide amphiphile nanofiber matrices for cell entrapment [J].
Beniash, E ;
Hartgerink, JD ;
Storrie, H ;
Stendahl, JC ;
Stupp, SI .
ACTA BIOMATERIALIA, 2005, 1 (04) :387-397
[4]   Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2 [J].
Cao, RH ;
Bråkenhielm, E ;
Pawliuk, R ;
Wariaro, D ;
Post, MJ ;
Wahlberg, E ;
Leboulch, P ;
Cao, YH .
NATURE MEDICINE, 2003, 9 (05) :604-613
[5]   MOLECULAR MODELING OF PROTEIN-GLYCOSAMINOGLYCAN INTERACTIONS [J].
CARDIN, AD ;
WEINTRAUB, HJR .
ARTERIOSCLEROSIS, 1989, 9 (01) :21-32
[6]   Angiogenesis in cancer and other diseases [J].
Carmeliet, P ;
Jain, RK .
NATURE, 2000, 407 (6801) :249-257
[7]   Tissue engineering strategies for in vivo neovascularisation [J].
Ennett, AB ;
Mooney, DJ .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2002, 2 (08) :805-818
[8]   The biology of VEGF and its receptors [J].
Ferrara, N ;
Gerber, HP ;
LeCouter, J .
NATURE MEDICINE, 2003, 9 (06) :669-676
[9]   Clinical applications of angiogenic growth factors and their inhibitors [J].
Ferrara, N ;
Alitalo, K .
NATURE MEDICINE, 1999, 5 (12) :1359-1364
[10]   ANGIOGENIC FACTORS [J].
FOLKMAN, J ;
KLAGSBRUN, M .
SCIENCE, 1987, 235 (4787) :442-447