Endothelin-B (ETB) receptor distribution in tissues of the lizard Podarcis sicula

被引:7
作者
De Falco, M
Laforgia, V
Fedele, V
Russo, T
De Luca, L
Cottone, G
Lorenzo, V
De Luca, A
机构
[1] Second Univ Naples, Sch Med, Inst Topog Anat, I-80138 Naples, Italy
[2] Univ Naples Federico II, Dept Evolut & Comparat Biol, Naples, Italy
[3] Ist Regina Elena, Ctr Expt Res, Lab C, I-00161 Rome, Italy
关键词
endothelin receptor; reptiles; immunohistochemistry; immunoblotting; Podarcis siculaa (lacertilia);
D O I
10.1007/s00441-002-0603-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Although the structural and pharmacological properties of endothelin (ET) receptors have been studied, little is known concerning their physiological significance, even if each subtype is supposed to have a distinct physiological action. Thus, to further elucidate the physiological function of this receptor, we examined the presence and distribution of the endothelin-B receptor (ETB) subtype in tissues of the lizard Podarcis sicula, using immunoblotting and immunohistochemistry. Immunoblotting indicated that, although the ETB receptor appears to be ubiquitous, it is present at different levels in the tissues examined. Furthermore, immunohistochemistry showed that this receptor is very abundant in endothelial cells of all tissues, suggesting that there is an ETB-mediated autocrine system of endothelin, which plays an important role in the regulation of endothelial cell function. On the other hand, the presence of ETB immunoreactivity also in endocrine systems such as adrenal and thyroid glands suggests an involvement also in the paracrine system of these organs.
引用
收藏
页码:381 / 386
页数:6
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