Triple check for antigen specificity of B cells during germinal centre reactions

被引：82

作者：

Lindhout, E

Koopman, G

Pals, ST

deGroot, C

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT PATHOL,NL-1105 AZ AMSTERDAM,NETHERLANDS

[2] UNIV AMSTERDAM,ACAD MED CTR,DEPT HISTOL & CELL BIOL,NL-1105 AZ AMSTERDAM,NETHERLANDS

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 12期

关键词：

D O I：

10.1016/S0167-5699(97)01160-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Somatic hypermutation of the immunoglobulin variable genes during germinal reactions might permit the expansion of B-cell clones with unwanted (e.g. autoreactive) specificity. Here, Ernst Lindhout and colleagues propose three antigen-specific checkpoints that ensure the appropriate antigen specificity of activated B cells is maintained by regulating the activation, selection and further differentiation of B cells.

引用

页码：573 / 577

页数：5

共 35 条

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