CD4+ CD25+ T-Cell production in healthy humans and in patients with thymic hypoplasia

被引：68

作者：

Sullivan, KE

McDonald-McGinn, D

Zackai, EH

机构：

[1] Childrens Hosp Philadelphia, Div Infect Dis & Immunol, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Div Clin Genet, Philadelphia, PA 19104 USA

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2002年 / 9卷 / 05期

关键词：

D O I：

10.1128/CDLI.9.5.1129-1131.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells are found primarily in the CD4(+) CD25(+) fraction of T cells and play an important role in the prevention of autoimmunity. We examined CD4(+) CD25(+) T cells in 33 healthy children and adults and compared them to a population with an inherited form of thymic hypoplasia and a predisposition to autoimmune disease. Absolute numbers of CD4(+) CD25(+) T cells were markedly higher in healthy infants than in infants with chromosome 22q11.2 deletion syndrome.

引用

页码：1129 / 1131

页数：3

共 7 条

[1] Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
Asano, M
Toda, M
Sakaguchi, N
Sakaguchi, S
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) : 387 - 396
[2] CD4+CD25high regulatory cells in human peripheral blood
Baecher-Allan, C
Brown, JA
Freeman, GJ
Hafler, DA
[J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (03) : 1245 - 1253
[3] Immunologic features of chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome)
Jawad, AF
McDonald-McGinn, DM
Zackai, E
Sullivan, KE
[J]. JOURNAL OF PEDIATRICS, 2001, 139 (05) : 715 - 723
[4] Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
Jordan, MS
Boesteanu, A
Reed, AJ
Petrone, AL
Holenbeck, AE
Lerman, MA
Naji, A
Caton, AJ
[J]. NATURE IMMUNOLOGY, 2001, 2 (04) : 301 - 306
[5] Regulatory T cells in the control of immune pathology
Maloy, KJ
Powrie, F
[J]. NATURE IMMUNOLOGY, 2001, 2 (09) : 816 - 822
[6] Certified professionals:: CD4+CD25+ suppressor T cells
Shevach, EM
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (11) : F41 - F45
[7] Lack of correlation between impaired T cell production, immunodeficiency, and other phenotypic features in chromosome 22q11.2 deletion syndromes (DiGeorge Syndrome Velocardiofacial syndrome)
Sullivan, KE
Jawad, AF
Randall, P
Driscoll, DA
Emanuel, BS
McDonald-McGinn, DM
Zackai, EH
[J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1998, 86 (02): : 141 - 146

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