Small organic molecules that modulate gene transcription

被引:8
作者
Jung, Dongju
Choi, Yongmun
Uesugi, Motonari [1 ]
机构
[1] Baylor Coll Med, Verna & Marrs Mclean Dept Biochem & Mol Biol, Houston, TX 77030 USA
[2] Kyoto Univ, Inst Chem Res, Uji, Kyoto 6110011, Japan
关键词
D O I
10.1016/j.drudis.2006.03.011
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Regulation of gene expression by transcription factors touches all aspects of human biology and often induces extreme phenotypes. Its external, precise control by small organic molecules represents a challenge in chemistry and biology. Here, we summarize recent progress in the field, together with contributions from our laboratory. Small-molecule modulators of transcription, including small-molecule transcription factors could find their use in basic biological studies and therapeutic intervention.
引用
收藏
页码:452 / 457
页数:6
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