Small organic molecules that modulate gene transcription

被引：8

作者：

Jung, Dongju

Choi, Yongmun

Uesugi, Motonari ^{[1
]}

机构：

[1] Baylor Coll Med, Verna & Marrs Mclean Dept Biochem & Mol Biol, Houston, TX 77030 USA

[2] Kyoto Univ, Inst Chem Res, Uji, Kyoto 6110011, Japan

来源：

DRUG DISCOVERY TODAY | 2006年 / 11卷 / 9-10期

关键词：

D O I：

10.1016/j.drudis.2006.03.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Regulation of gene expression by transcription factors touches all aspects of human biology and often induces extreme phenotypes. Its external, precise control by small organic molecules represents a challenge in chemistry and biology. Here, we summarize recent progress in the field, together with contributions from our laboratory. Small-molecule modulators of transcription, including small-molecule transcription factors could find their use in basic biological studies and therapeutic intervention.

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页码：452 / 457

页数：6

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