Family-based analysis of tumor necrosis factor and lymphotoxin-α tag polymorphisms with type 1 diabetes in the population of South Croatia

被引：15

作者：

Boraska, Vesna ^{[1
]}

Zeggini, Eleftheria ^{[2
,3
]}

Groves, Christopher J. ^{[4
]}

Rayner, Nigel W. ^{[2
]}

Skrabic, Veselin ^{[5
]}

Diakite, Mahamadou ^{[2
]}

Rockett, Kirk A. ^{[2
]}

Kwiatkowski, Dominic ^{[2
,3
]}

McCarthy, Mark I. ^{[2
,4
]}

Zemunik, Tatijana ^{[1
]}

机构：

[1] Univ Split, Dept Med Biol, Sch Med, Split, Croatia

[2] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England

[3] Wellcome Trust Sanger Inst, Cambridge, England

[4] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England

[5] Clin Hosp Split, Dept Pediat, Split, Croatia

来源：

HUMAN IMMUNOLOGY | 2009年 / 70卷 / 03期

基金：

英国惠康基金;

关键词：

Type; 1; diabetes; Tumor necrosis factor; Lymphotoxin alpha; TDT; Tag polymorphism; LINKAGE DISEQUILIBRIUM; PROMOTER POLYMORPHISM; CLASS-II; HLA-B; ASSOCIATION; GENE; TNF; SUSCEPTIBILITY; HAPLOTYPES; LOCUS;

D O I：

10.1016/j.humimm.2008.12.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) are cytokines with a wide range of inflammatory and immunomodulatory activities. Type 1 diabetes is an autoimmune disease characterized by destruction of insulin-producing pancreatic beta cells. The aim of the present study was to evaluate the association of polymorphisms in the TNF/LTA gene region with susceptibility to type 1 diabetes. We investigated 11 TNF/LTA tag polymorphisms, designed to capture the majority of common variation in the region, in 160 trio families from South Croatia. We observed overtransmission of alleles from parents to affected child at five variants: (rs909253, allele C, p = 1.2 X 10(-4); rs1041981, allele A, p = 1.1 X 10(-4); rs1800629 (G-308A), allele A, p = 1.2 X 10(-4); rs361525 (G-238A), allele G, p = 8.2 X 10(-3) and rs3093668, allele G, p = 0.014). We also identified overtransmission of the rs1800629(G-308A)-rs361525(G-238A) A-G haplotype, p = 2.384 X 10(-5). The present study found an association of the TNF/LTA gene region with type 1 diabetes. A careful assessment of TNF/LTA variants adjusted for linkage disequilibrium with HLA loci is needed to further clarify the role of these genes in type 1 diabetes susceptibility in the population of South Croatia. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：195 / 199

页数：5

共 39 条

[1]

Am Diabetes Assoc, 2006, DIABETES CARE, V29, pS4

[2]

The International HapMap Project [J].

Gibbs, RA ;

Belmont, JW ;

Hardenbol, P ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Ch'ang, LY ;

Huang, W ;

Liu, B ;

Shen, Y ;

Tam, PKH ;

Tsui, LC ;

Waye, MMY ;

Wong, JTF ;

Zeng, CQ ;

Zhang, QR ;

Chee, MS ;

Galver, LM ;

Kruglyak, S ;

Murray, SS ;

Oliphant, AR ;

Montpetit, A ;

Hudson, TJ ;

Chagnon, F ;

Ferretti, V ;

Leboeuf, M ;

Phillips, MS ;

Verner, A ;

Kwok, PY ;

Duan, SH ;

Lind, DL ;

Miller, RD ;

Rice, JP ;

Saccone, NL ;

Taillon-Miller, P ;

Xiao, M ;

Nakamura, Y ;

Sekine, A ;

Sorimachi, K ;

Tanaka, T ;

Tanaka, Y ;

Tsunoda, T ;

Yoshino, E ;

Bentley, DR ;

Deloukas, P ;

Hunt, S ;

Powell, D ;

Altshuler, D ;

Gabriel, SB ;

Qiu, RZ .

NATURE, 2003, 426 (6968) :789-796

[3]

Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[4]

TNFA-TNFB haplotypes modify susceptibility to type I diabetes mellitus independently of HLA class II in a Moroccan population [J].

Bouqbis, L ;

Akhayat, O ;

Garchon, HJ ;

Calafell, F ;

Izaabel, H .

TISSUE ANTIGENS, 2003, 61 (01) :72-79

[5]

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[6]

Association of -308 TNF-α promoter polymorphism with type 1 diabetes in North Indians [J].

Das, S. N. ;

Baniasadi, V. ;

Kapuria, V. .

INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2006, 33 (06) :411-416

[7]

Efficiency and power in genetic association studies [J].

de Bakker, PIW ;

Yelensky, R ;

Pe'er, I ;

Gabriel, SB ;

Daly, MJ ;

Altshuler, D .

NATURE GENETICS, 2005, 37 (11) :1217-1223

[8]

DEJA G, 2006, MEDIAT INFLAMM, P1

[9]

No primary association between the 308 polymorphism in the tumor necrosis factor alpha promoter region and insulin-dependent diabetes mellitus [J].

Deng, GY ;

Maclaren, NK ;

Huang, HS ;

Zhang, LP ;

She, JX .

HUMAN IMMUNOLOGY, 1996, 45 (02) :137-142

[10]

Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin [J].

De Togni, Pietro ;

Goellner, Josphe ;

Ruddle, Nancy H. ;

Streeter, Philip R. ;

Fick, Andrea ;

Mariathasan, Sanjeev ;

Smith, Stacy C. ;

Carison, Rebecca ;

Shonnick, Laurie P. ;

strauss-Schoenberger, Jena ;

Russell, John H. ;

Karr, Robert ;

Chaplin, David D. .

JOURNAL OF IMMUNOLOGY, 2014, 192 (05) :2010-2014

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