Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

被引：5031

作者：

Doehner, Hartmut ^{[1
]}

Estey, Elihu ^{[2
]}

Grimwade, David ^{[3
]}

Amadori, Sergio ^{[4
]}

Appelbaum, Frederick R. ^{[2
]}

Buechner, Thomas ^{[5
]}

Dombret, Herve ^{[6
]}

Ebert, Benjamin L. ^{[7
]}

Fenaux, Pierre ^{[8
]}

Larson, Richard A. ^{[9
]}

Levine, Ross L. ^{[10
]}

Lo-Coco, Francesco ^{[4
]}

Naoe, Tomoki ^{[11
]}

Niederwieser, Dietger ^{[12
]}

Ossenkoppele, Gert J. ^{[13
]}

Sanz, Miguel ^{[14
]}

Sierra, Jorge ^{[15
]}

Tallman, Martin S. ^{[10
]}

Tien, Hwei-Fang ^{[16
]}

Wei, Andrew H. ^{[17
,18
]}

Lowenberg, Bob ^{[19
]}

Bloomfield, Clara D. ^{[20
]}

机构：

[1] Univ Ulm, Dept Internal Med 3, Albert Einstein Allee 23, D-89081 Ulm, Germany

[2] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA

[3] Kings Coll London, Fac Life Sci & Med, Dept Med & Mol Genet, London, England

[4] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy

[5] Univ Munster, Dept Hematol Oncol, Munster, Germany

[6] Hop St Louis, AP HP, Inst Univ Hematol, Paris, France

[7] Harvard Med Sch, Brigham & Womens Hosp, Div Hematol, Dept Med, Boston, MA USA

[8] Hop St Louis, Serv Hematol, Paris, France

[9] Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA

[10] Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, 1275 York Ave, New York, NY 10021 USA

[11] Natl Hosp Org, Nagoya Med Ctr, Nagoya, Aichi, Japan

[12] Univ Leipzig, Dept Hematol Oncol & Hemostasis, Leipzig, Germany

[13] Vrije Univ, Univ Med Ctr, Dept Haematol, Amsterdam, Netherlands

[14] Univ Valencia, Univ Hosp La Fe, Dept Hematol, Valencia, Spain

[15] Hosp Santa Creu & Sant Pau, Dept Hematol, Jose Carreras Leukemia Res Inst, Barcelona, Spain

[16] Natl Taiwan Univ Hosp, Dept Internal Med, Div Hematol, Taipei, Taiwan

[17] Alfred Hosp, Dept Clin Hematol, Melbourne, Vic, Australia

[18] Monash Univ, Australian Ctr Blood Dis, Melbourne, Vic, Australia

[19] Erasmus Univ, Med Ctr, Dept Hematol, Rotterdam, Netherlands

[20] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

BLOOD | 2017年 / 129卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ACUTE MYELOID-LEUKEMIA; STEM-CELL TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; HIGH-DOSE CYTARABINE; CONVENTIONAL CARE REGIMENS; ACUTE MYELOGENOUS LEUKEMIA; SINGLE CEBPA MUTATIONS; BUSULFAN PLUS CYCLOPHOSPHAMIDE; THERAPY-RELATED MYELODYSPLASIA; DONOR LYMPHOCYTE INFUSION;

D O I：

10.1182/blood-2016-08-733196

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults, published in 2010, has found broad acceptance by physicians and investigators caring for patients with AML. Recent advances, for example, in the discovery of the genomic landscape of the disease, in the development of assays for genetic testing and for detecting minimal residual disease (MRD), as well as in the development of novel antileukemic agents, prompted an international panel to provide updated evidence-and expert opinion-based recommendations. The recommendations include a revised versionof theELNgenetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.

引用

页码：424 / 447

页数：24

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