Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis; the role of basic cofactors

被引：39

作者：

Fanning, Ann-Marie ^{[1
]}

Plush, Sally E. ^{[1
]}

Gunnlaugsson, Thorfinnur ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 36期

关键词：

D O I：

10.1039/b609923h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of several cyclen based lanthanide [Eu( III) and La( III)] complexes is described; these metallo ribonuclease mimics are based on the use of alkyl amines as pendent arms, which give rise to fast hydrolysis within the physiological pH range of HPNP ( an RNA model compound) that is highly dependent on the length of the alkyl spacer.

引用

页码：3791 / 3793

页数：3

共 29 条

[1]

AMIN PS, 1994, ANGEW CHEM INT EDIT, V33, P773

[2]

Baskin J.K., 1999, CURR OPIN CHEM BIOL, V3, P752

[3] Non-radiative deactivation of the excited states of europium, terbium and ytterbium complexes by proximate energy-matched OH, NH and CH oscillators: an improved luminescence method for establishing solution hydration states [J].

Beeby, A ;

Clarkson, IM ;

Dickins, RS ;

Faulkner, S ;

Parker, D ;

Royle, L ;

de Sousa, AS ;

Williams, JAG ;

Woods, M .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1999, (03) :493-503

[4] Bioinspired hydrogen bond motifs in ligand design: The role of noncovalent interactions in metal ion mediated activation of dioxygen [J].

Borovik, AS .

ACCOUNTS OF CHEMICAL RESEARCH, 2005, 38 (01) :54-61

[5] Ternary complexes between cationic GdIII chelates and anionic metabolites in aqueous solution:: An NMR relaxometric study [J].

Botta, M ;

Aime, S ;

Barge, A ;

Bobba, G ;

Dickins, RS ;

Parker, D ;

Terreno, E .

CHEMISTRY-A EUROPEAN JOURNAL, 2003, 9 (09) :2102-2109

[6]

Breslow R, 2005, ARTIFICIAL ENZYMES, P1, DOI 10.1002/3527606645

[7] EFFECTS OF METAL-IONS, INCLUDING MG2+ AND LANTHANIDES, ON THE CLEAVAGE OF RIBONUCLEOTIDES AND RNA MODEL COMPOUNDS [J].

BRESLOW, R ;

HUANG, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4080-4083

[8] DEVELOPING ARTIFICIAL HYDROLYTIC METALLOENZYMES BY A UNIFIED MECHANISTIC APPROACH [J].

CHIN, J .

ACCOUNTS OF CHEMICAL RESEARCH, 1991, 24 (05) :145-152

[9] Comparing a mononuclear Zn(II) complex with hydrogen bond donors with a dinuclear Zn(II) complex for catalysing phosphate ester cleavage [J].

Feng, GQ ;

Mareque-Rivas, JC ;

Williams, NH .

CHEMICAL COMMUNICATIONS, 2006, (17) :1845-1847

[10] A highly reactive mononuclear Zn(II) complex for phosphodiester cleavage [J].

Feng, GQ ;

Mareque-Rivas, JC ;

de Rosales, RTM ;

Williams, NH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (39) :13470-13471

← 1 2 3 →