Liposomal Bupivacaine Versus Traditional Periarticular Injection for Pain Control After Total Knee Arthroplasty

被引：124

作者：

Bagsby, Deren T. ^{[1
]}

Ireland, Phillip H. ^{[1
]}

Meneghini, R. Michael ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Dept Orthopaed Surg, Indiana Univ Hlth Phys, Indianapolis, IN 46202 USA

来源：

JOURNAL OF ARTHROPLASTY | 2014年 / 29卷 / 08期

关键词：

knee arthroplasty; periarticular injection; pain control; bupivacaine; liposomal; MULTIMODAL DRUG INJECTION; PERIPHERAL-NERVE BLOCK; DOUBLE-BLIND; TOTAL HIP; POSTSURGICAL ANALGESIA; MANAGEMENT; TRIAL; HEMORRHOIDECTOMY; ANESTHESIA; EFFICACY;

D O I：

10.1016/j.arth.2014.03.034

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

The purpose of this study was to compare a novel liposomal bupivacaine to traditional peri-articular injection (PAI) in a multi-modal pain protocol for total knee arthroplasty (TKA). A retrospective cohort study compared 85 consecutive patients undergoing TKA with a traditional PAI of ropivacaine, epinephrine and morphine to 65 patients with a liposomal bupivacaine PAI. After the initial 24 h, inpatient self-reported pain scores were higher in the liposomal bupivacaine group compared to the traditional PAI group (P = 0.04) and a smaller percentage (16.9%) of patients in the liposomal bupivacaine group rated their pain as "mild" compared to the traditional group (47.6%). Liposomal bupivacaine PAI provided inferior pain control compared to the less expensive traditional PAI in a multi-modal pain control program in patients undergoing TKA. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：1687 / 1690

页数：4

共 20 条

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[2]

A randomized, double-blind, dose-ranging study comparing wound infiltration of DepoFoam bupivacaine, an extended-release liposomal bupivacaine, to bupivacaine HCl for postsurgical analgesia in total knee arthroplasty [J].