Liposomal Bupivacaine Versus Traditional Periarticular Injection for Pain Control After Total Knee Arthroplasty

被引:124
作者
Bagsby, Deren T. [1 ]
Ireland, Phillip H. [1 ]
Meneghini, R. Michael [1 ]
机构
[1] Indiana Univ Sch Med, Dept Orthopaed Surg, Indiana Univ Hlth Phys, Indianapolis, IN 46202 USA
关键词
knee arthroplasty; periarticular injection; pain control; bupivacaine; liposomal; MULTIMODAL DRUG INJECTION; PERIPHERAL-NERVE BLOCK; DOUBLE-BLIND; TOTAL HIP; POSTSURGICAL ANALGESIA; MANAGEMENT; TRIAL; HEMORRHOIDECTOMY; ANESTHESIA; EFFICACY;
D O I
10.1016/j.arth.2014.03.034
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
100224 [整形外科学];
摘要
The purpose of this study was to compare a novel liposomal bupivacaine to traditional peri-articular injection (PAI) in a multi-modal pain protocol for total knee arthroplasty (TKA). A retrospective cohort study compared 85 consecutive patients undergoing TKA with a traditional PAI of ropivacaine, epinephrine and morphine to 65 patients with a liposomal bupivacaine PAI. After the initial 24 h, inpatient self-reported pain scores were higher in the liposomal bupivacaine group compared to the traditional PAI group (P = 0.04) and a smaller percentage (16.9%) of patients in the liposomal bupivacaine group rated their pain as "mild" compared to the traditional group (47.6%). Liposomal bupivacaine PAI provided inferior pain control compared to the less expensive traditional PAI in a multi-modal pain control program in patients undergoing TKA. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:1687 / 1690
页数:4
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