Intracerebral hemorrhages associated with neurointerventional procedures using a combination of antithrombotic agents including abciximab

被引:65
作者
Qureshi, AI
Saad, M
Zaidat, OO
Suarez, JI
Alexander, MJ
Suri, MFK
Ali, Z
Hopkins, LN
机构
[1] SUNY Buffalo, Sch Med & Biomed Sci, Dept Neurosurg, Buffalo, NY 14209 USA
[2] SUNY Buffalo, Sch Med & Biomed Sci, Toshiba Stroke Res Ctr, Buffalo, NY 14209 USA
[3] Univ Hosp Cleveland, Dept Neurol, Cleveland, OH 44106 USA
[4] Duke Univ, Div Neurosurg, Durham, NC USA
关键词
abciximab; angioplasty; carotid stenosis; intracerebral hemorrhage; stents;
D O I
10.1161/01.STR.0000019423.08947.43
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background-We report the occurrence of fatal intracerebral hemorrhage associated with using a combination of antithrombotic agents, including abciximab, in patients undergoing neurointerventional procedures. Summary of Report-Seven patients (average age 60, range 46 to 73 years) developed fatal intracerebral hemorrhages associated with neurointerventional procedures and the use of intravenous abciximab. The procedures included angioplasty and stent placement in the cervical internal carotid artery (n=4), angioplasty of the intracranial internal carotid artery (n=1), and angioplasty of the middle cerebral artery (n=2). Clinical deterioration was observed within 1 hour of the procedure in 5 patients and 7 and 8 hours after the procedure, respectively, in the remaining 2 patients. All patients had received heparin and clopidogrel; 6 had also received aspirin. Conclusions-Intracerebral hemorrhages can occur after neurointerventional procedures in patients with recent cerebral ischemic events, particularly when aggressive anti thrombotic treatment is used.
引用
收藏
页码:1916 / 1919
页数:4
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