Early immunisation with hepatitis B vaccine: a five-year study

被引：24

作者：

Belloni, C

Pistorio, A

Tinelli, C

Komakec, J

Chirico, G

Rovelli, D

Gulminetti, R

Comolli, G

Orsolini, P

Rondini, G

机构：

[1] IRCCS San Matteo, Div Neonatal Intens Care, I-27100 Pavia, Italy

[2] IRCCS San Matteo, Sci Direct, Biometry Unit, Pavia, Italy

[3] IRCCS San Matteo, Infect Dis Area, Expt Res Labs, Pavia, Italy

[4] IRCCS San Matteo, Biotechnol Area, Expt Res Labs, Pavia, Italy

[5] IRCCS San Matteo, Dept Infect Dis, Pavia, Italy

[6] Univ Pavia, Dept Pediat, I-27100 Pavia, Italy

来源：

VACCINE | 2000年 / 18卷 / 14期

关键词：

hepatitis B vaccines; immunologic memory; immunisation schedule;

D O I：

10.1016/S0264-410X(99)00414-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers. At seroconversion, the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule. After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases. Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1307 / 1311

页数：5

共 29 条

[1]

ANDRE FE, 1988, VIRAL HEPATITIS LIVE, P1025

[2] Revaccination against hepatitis B virus of non-responding and low-responding infants immunised at birth. A parallel evaluation of rubella and tetanus vaccine [J].