PrPSc accumulation in myocytes from sheep incubating natural scrapie

被引：107

作者：

Andréoletti, O

Simon, S

Lacroux, C

Morel, N

Tabouret, G

Chabert, A

Lugan, S

Corbière, F

Ferré, P

Foucras, G

Laude, H

Eychenne, F

Grassi, J

Schelcher, F

机构：

[1] Ecole Natl Vet Toulouse, UMR INRA ENVT 1225, F-31076 Toulouse, France

[2] CEA Saclay, DRM, Serv Pharmacol & Immunol, F-91191 Gif Sur Yvette, France

[3] Ecole Natl Vet Toulouse, UMR INRA ENVT 181, F-31076 Toulouse, France

[4] INRA, F-78350 Jouy En Josas, France

[5] INRA, F-31450 Pompertuzat, France

来源：

NATURE MEDICINE | 2004年 / 10卷 / 06期

关键词：

D O I：

10.1038/nm1055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Because variant Creutzfeldt-Jakob disease (vCJD) in humans probably results from consumption of products contaminated with tissue from animals with bovine spongiform encephalopathy, whether infectious prion protein is present in ruminant muscles is a crucial question. Here we show that experimentally and naturally scrapie-affected sheep accumulate the prion protein PrPSc in a myocyte subset. In naturally infected sheep, PrPSc is detectable in muscle several months before clinical disease onset. The relative amounts of PrPSc suggest a 5,000-fold lower infectivity for muscle as compared to brain.

引用

收藏

页码：591 / 593

页数：3

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