Model-based reconstructive elasticity imaging of deep venous thrombosis

被引:23
作者
Aglyamov, S [1 ]
Skovoroda, AR
Rubin, JM
O'Donnell, M
Emelianov, SY
机构
[1] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA
[3] Russian Acad Sci, Inst Math Problems Biol, Pushchino 142290, Moscow Region, Russia
[4] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[5] Russian Acad Sci, Inst Math Problems Biol, Pushchino 142290, Moscow Region, Russia
关键词
D O I
10.1109/TUFFC.2004.1320825
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
Deep venous thrombosis (DVT) and its sequela, pulmonary embolism, is a significant clinical problem. Once detected, DVT treatment is based on the age of the clot. There are no good noninvasive methods, however, to determine clot age. Previously, we demonstrated that imaging internal mechanical strains can identify and possibly age thrombus in a deep vein. In this study the deformation geometry for DVT elasticity imaging and its effect on Young's modulus estimates is addressed. A model-based reconstruction method is presented to estimate elasticity in which the clot-containing vessel is modeled as a layered cylinder. Compared to an unconstrained approach in reconstructive elasticity imaging, the proposed model-based approach has several advantages: only one component of the strain tensor is used; the minimization procedure is very fast; the method is highly efficient because an analytic solution of the forward elastic problem is used; and the method is not very sensitive to the details of the external load pattern-a characteristic that is important for free-hand, external, surface-applied deformation. The approach was tested theoretically using a numerical model, and experimentally on both tissue-like phantoms and an animal model of DVT. Results suggest that elasticity reconstruction may prove to be a practical adjunct to triplex scanning to detect, diagnose, and stage DVT.
引用
收藏
页码:521 / 531
页数:11
相关论文
共 24 条
[1]  
AGLYAMOV SR, 2002, ULTRASONIC IMAGING, V22, P174
[2]   Triplex ultrasound: Elasticity imaging to age deep venous thrombosis [J].
Emelianov, SY ;
Chen, X ;
O'Donnell, M ;
Knipp, B ;
Myers, D ;
Wakefield, TW ;
Rubin, JM .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2002, 28 (06) :757-767
[3]  
Emelianov SY, 2000, ULTRASON, P1791, DOI 10.1109/ULTSYM.2000.921670
[4]   Measuring the elastic modulus of small tissue samples [J].
Erkamp, RQ ;
Wiggins, P ;
Skovoroda, AR ;
Emelianov, SY ;
O'Donnell, M .
ULTRASONIC IMAGING, 1998, 20 (01) :17-28
[5]  
Goodier J.N., 1933, J APPL MECH-T ASME, V55, P39, DOI [10.1115/1.4012173, DOI 10.1115/1.4012173]
[7]   HEPARIN FOR 5 DAYS AS COMPARED WITH 10 DAYS IN THE INITIAL TREATMENT OF PROXIMAL VENOUS THROMBOSIS [J].
HULL, RD ;
RASKOB, GE ;
ROSENBLOOM, D ;
PANJU, AA ;
BRILLEDWARDS, P ;
GINSBERG, JS ;
HIRSH, J ;
MARTIN, GJ ;
GREEN, D .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (18) :1260-1264
[8]   Antithrombotic therapy for venous thromboembolic disease [J].
Hyers, TM ;
Agnelli, G ;
Hull, RD ;
Weg, JG ;
Morris, TA ;
Samama, M ;
Tapson, V .
CHEST, 1998, 114 (05) :561S-578S
[9]   Tissue elasticity reconstruction using linear perturbation method [J].
Kallel, F ;
Bertrand, M .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 1996, 15 (03) :299-313
[10]   A new elastographic method for estimation and imaging of lateral displacements, lateral strains, corrected axial strains and Poisson's ratios in tissues [J].
Konofagou, E ;
Ophir, J .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1998, 24 (08) :1183-1199