Rapid genotypic detection of rifampin- and isoniazid-resistant Mycobacterium tuberculosis directly in clinical specimens

被引：52

作者：

Bang, Didi

Andersen, Ase Bengard

Thomsen, Vibeke Ostergaard

机构：

[1] Statens Serum Inst, Int Reference Lab Mycobacteriol, Natl Inst Prevent & Control Infect Dis & Congenit, DK-2300 Copenhagen S, Denmark

[2] Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2006年 / 44卷 / 07期

关键词：

D O I：

10.1128/JCM.00752-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A multiplex PCR DNA strip assay (Genotype MTBDR) designed to detect rifampin (rpoB) and high-level isoniazid (katG) resistance mutations in Mycobacterium tuberculosis isolates was optimized for clinical specimens. Successful genotypic results were achieved with 36 of 38 (95%) smear-positive respiratory. specimens. allowing rapid therapeutic adjustments in transmittable drug-resistant tuberculosis.

引用

页码：2605 / 2608

页数：4

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