Poly(N-(2-hydroxypropyl) methacrylamide mono/di lactate):: A new class of biodegradable polymers with tuneable thermosensitivity

被引：88

作者：

Soga, O ^{[1
]}

van Nostrum, CF ^{[1
]}

Hennink, WE ^{[1
]}

机构：

[1] Univ Utrecht, Fac Pharmaceut Sci, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3508 TB Utrecht, Netherlands

来源：

BIOMACROMOLECULES | 2004年 / 5卷 / 03期

关键词：

D O I：

10.1021/bm049955q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel class of thermosensitive and biodegradable polymers, poly(N-(2-hydroxypropyl) methacrylamide mono/di lactate) (poly(HPMAm-mono/di lactate)), was synthesized. The cloud points (CP) of poly(HPMAm-monolactate) and poly(HPMAm-dilactate) in water were 65 and 13degreesC, respectively. The lower CP for poly(HPMAm-dilactate) is likely due the greater hydrophobicity of the dilactate side group over the monolactate side group. The CP of poly(HPMAm-monolactate-co-HPMAm-dilactate) increased linearly with mol % of HPMA-monolactate, which demonstrates that the CP is tuneable by the copolymer composition.

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页码：818 / 821

页数：4

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