Concomitant changes in CRH mRNA levels in rat hippocampus and hypothalamus following immobilization stress

被引：69

作者：

Givalois, L ^{[1
]}

Arancibia, S ^{[1
]}

Tapia-Arancibia, L ^{[1
]}

机构：

[1] Univ Montpellier 2, Cerebral Plast Lab, CNRS, EP 628, F-34095 Montpellier, France

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 75卷 / 01期

关键词：

corticotropin-releasing hormone; hippocampus; immobilization stress; in situ hybridization; MK-801; N-methyl-D-aspartic acid;

D O I：

10.1016/S0169-328X(99)00290-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By using in situ hybridization, we have demonstrated an increased expression of corticotropin-releasing hormone (CRH) mRNA in the hippocampus following immobilization stress (3 h) in rats. It paralleled that measured in the hypothalamic paraventricular nucleus (PVN). Pretreatment of control and stressed rats with MK-801 (a NMDA receptor antagonist) further increased CRH mRNA expression, in the two structures. The concomitant up-regulation of CRH mRNA expression in these structures suggests a common regulatory finality for a single molecule at two different loci. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：166 / 171

页数：6

共 32 条

[1] Corticotropin releasing hormone, receptor regulation and the stress response [J].

Aguilera, G .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1998, 9 (08) :329-336

[2]

Albeck DS, 1997, J NEUROSCI, V17, P4895

[3] Neuroendocrine and autonomous mechanisms underlying thermoregulation in cold environment [J].

Arancibia, S ;

Rage, F ;

Astier, H ;

TapiaArancibia, L .

NEUROENDOCRINOLOGY, 1996, 64 (04) :257-267

[4] Neuropeptide-mediated excitability: a key triggering mechanism for seizure generation in the developing brain [J].

Baram, TZ ;

Hatalski, CG .

TRENDS IN NEUROSCIENCES, 1998, 21 (11) :471-476

[5] UP-REGULATION OF VASOPRESSIN MESSENGER-RNA IN PARAVENTRICULAR HYPOPHYSIOTROPHIC NEURONS AFTER ACUTE IMMOBILIZATION STRESS [J].

BARTANUSZ, V ;

AUBRY, JM ;

JEZOVA, D ;

BAFFI, J ;

KISS, JZ .

NEUROENDOCRINOLOGY, 1993, 58 (06) :625-629

[6] STRESS-INDUCED CHANGES IN MESSENGER-RNA LEVELS OF N-METHYL-D-ASPARTATE AND AMPA RECEPTOR SUBUNITS IN SELECTED REGIONS OF THE RAT HIPPOCAMPUS AND HYPOTHALAMUS [J].

BARTANUSZ, V ;

AUBRY, JM ;

PAGLIUSI, S ;

JEZOVA, D ;

BAFFI, J ;

KISS, JZ .

NEUROSCIENCE, 1995, 66 (02) :247-252

[7] ROLE OF SOMATOSTATIN IN THE ACUTE IMMOBILIZATION STRESS-INDUCED GH DECREASE IN RAT [J].

BENYASSI, A ;

GAVALDA, A ;

ARMARIO, A ;

ARANCIBIA, S .

LIFE SCIENCES, 1993, 52 (04) :361-370

[8] DIFFERENTIAL-EFFECTS OF MK-801 ON BRAIN-DERIVED NEUROTROPHIC FACTOR MESSENGER-RNA LEVELS IN DIFFERENT REGIONS OF THE RAT-BRAIN [J].

CASTREN, E ;

BERZAGHI, MD ;

LINDHOLM, D ;

THOENEN, H .

EXPERIMENTAL NEUROLOGY, 1993, 122 (02) :244-252

[9] Brain corticosteroid receptor balance in health and disease [J].

De Kloet, ER ;

Vreugdenhil, E ;

Oitzl, MS ;

Joëls, M .

ENDOCRINE REVIEWS, 1998, 19 (03) :269-301

[10] N-methyl-D-aspartate receptor involvement in dexamethasone and stress-induced hypothalamic somatostatin release in rats [J].

Estupina, C ;

Abarca, J ;

Arancibia, S ;

Belmar, J .

NEUROSCIENCE LETTERS, 1996, 219 (03) :203-206

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