New procedures for the synthesis of heterocyclic substituted and 2,4-difunctionalized pyrimidines

被引：15

作者：

Martinez, AG ^{[1
]}

Fernandez, AH ^{[1
]}

Jimenez, FM ^{[1
]}

Martinez, PJM ^{[1
]}

Martin, CA ^{[1
]}

Subramanian, LR ^{[1
]}

机构：

[1] UNIV TUBINGEN,INST ORGAN CHEM,D-72076 TUBINGEN,GERMANY

来源：

TETRAHEDRON | 1996年 / 52卷 / 23期

关键词：

D O I：

10.1016/0040-4020(96)00368-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Tosyl-2- and -3-acetylpyrrols 1 or N-tosyl-2-pyrrolidone 5 were condensed with cyano compounds in the presence of triflic anhydride (Tf(2)O) to yield heteroarylpyrimidines. 2,4-Difunctionalized pyrimidines were obtained by reaction of the corresponding 2,4-bis(methylsulfonyl)pyrimidines with nucleophiles. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：7973 / 7982

页数：10

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