Utilization of positron emission tomography in the management of patients with sarcoma

被引：70

作者：

Benz, Matthias R. ^{[2
,3
]}

Tchekmedyian, Nishan

Eilber, Fritz C. ^{[2
,3
,4
]}

Federman, Noah ^{[5
]}

Czernin, Johannes ^{[2
,3
]}

Tap, William D. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Div Med Oncol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Mol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Med Pharmacol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Div Surg Oncol, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Div Pediat Hematol Oncol, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN ONCOLOGY | 2009年 / 21卷 / 04期

关键词：

F-18-fluorodeoxyglucose; F-18-fluorothymidine; PET; sarcoma; SOFT-TISSUE SARCOMAS; NERVE SHEATH TUMORS; PRIMARY BONE-TUMORS; NEOADJUVANT THERAPY RESPONSE; FDG-PET; F-18; FLUORODEOXYGLUCOSE; LOCAL RECURRENCE; NEUROFIBROMATOSIS TYPE-1; MUSCULOSKELETAL TUMORS; CHEMOTHERAPY RESPONSE;

D O I：

10.1097/CCO.0b013e32832c95e2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose of review F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET) is being used with increased frequency in the care of patients with sarcoma. In this review, the recent literature covering all aspects of PET imaging in the management of patients with soft tissue and bone sarcomas will be discussed. Recent findings In a prospective multicenter study, PET imaging accurately detected primary tumors as well as lymph node and bone metastases in patients with sarcoma. Limitations in detecting lung metastasis can be overcome by using a hybrid PET/CT scanner. In patients with neurofibromatosis, F-18-FDG-PET demonstrated its application to detect and monitor for the malignant transformation of neurofibromas. Changes in tumor F-18-FDG uptake correlate significantly with histopathologic response and survival in patients with sarcoma. Summary PET imaging is emerging as an important imaging modality in the management of patients with sarcoma. Its applications include tumor grading, staging, therapeutic monitoring, and prognostication in adult and pediatric populations.

引用

页码：345 / 351

页数：7

共 68 条

[1]

ADLER LP, 1991, J NUCL MED, V32, P1508

[2]

Positron emission tomography/computed tomography with 18fluoro-deoxyglucose in the detection of local recurrence and distant metastases of pediatric sarcoma [J].