Modulatory effect of Ganoderma lucidum polysaccharides on serum antioxidant enzymes activities in ovarian cancer rats

被引：132

作者：

YouGuo, Chen ^{[1
]}

ZongJi, Shen ^{[1
]}

XiaoPing, Chen ^{[2
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Suzhou 215006, Peoples R China

[2] YanCheng 1th People Hosp, Dept Obstet & Gynecol, Yancheng City 224000, Jiangsu, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2009年 / 78卷 / 02期

关键词：

Polysaccharides from Ganoderma lucidum; Rat; Antioxidant; SOD; MDA; LYCIUM-BARBARUM POLYSACCHARIDES; OXIDATIVE STRESS; IN-VIVO; DAMAGE; MICE; PEPTIDES; EXERCISE; DNA;

D O I：

10.1016/j.carbpol.2009.03.030

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

In the present study, we isolated polysaccharides from Ganoderma lucidum and investigated its effect on serum antioxidant enzymes activity in ovarian cancer rats to explore the mechanism underlying the pharmacological anti-cancer activity of th\e polysaccharides. Rats were grouped into the control, model and polysaccharides-treated groups. After experiment ended, serum antioxidant enzymes activity in rats were measured. Results showed that polysaccharides from G. lucidum significantly reduced MDA production and increased serum antioxidant enzymes activity. These results suggest that the antioxidant activity of polysaccharides from G. lucidum might be benefical towards ovarian cancer therapy. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：258 / 262

页数：5

共 25 条

[1]

Antioxidant activities of Sophora subprosrate polysaccharide in immunosuppressed mice [J].