Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: relationship to type and tumour behaviour

被引:76
作者
de la Torre, N. Garcia
Buley, I.
Wass, J. A. H.
Turner, H. E.
机构
[1] Churchill Hosp, Dept Endocrinol, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England
[2] Hosp Clin San Carlos, Serv Endocrinol & Nutr, Madrid 28040, Spain
[3] Torbay Gen Hosp, Dept Histopathol, Torquay TQ2 7AA, Devon, England
关键词
ENDOTHELIAL GROWTH-FACTOR; LYMPH-NODE METASTASES; FACTOR-C; VEGF-C; INCREASED EXPRESSION; MESSENGER-RNA; IN-VITRO; CARCINOMA; PAPILLARY; CANCER;
D O I
10.1677/erc.1.01210
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The role of angiogenesis and lymphangiogenesis in thyroid cancer pathogenesis has not been elucidated. Patterns for tumour behaviour and metastasic spread vary according to tumour type and whether differences in the angiogenic or lymphangiogenic phenotype influence the route for tumour metastases or determine a more aggressive behaviour has not been fully explored. The angiogenic and lymphangiogenic phenotypes of a large cohort of thyroid proliferative lesions (n=191) were studied. Using immunohistochemistry for CD34, lymphatic vessel endothelial receptor-1 (LYVE-1) (specific markers for vascular and lymphatic endothelium respectively), vascular endothelial growth factor (VEGF-A), VEGF-C and fibroblast growth factor-2 (FGF-2), this study analyses microvascular density (MVD), lymphatic vascular density (LVD), and expression of angiogenic and lymphangiogenic factors in normal thyroid (NT; n=19), multinodular goitre (n=25), toxic multinodular goitre (n=8), Graves' hyperplasia (n=22),follicular adenoma (n=54),papillary carcinoma (PC; n=27), incidental papillary microcarcinoma (PMC; n=8), follicular carcinoma (FC; n=20) and medullary carcinoma (MC; n=8). MVD was decreased in proliferative lesions, benign and malignant, compared with NT (P < 0.0001). In contrast, VEGF-A expression was increased in thyroid carcinomas (PC, FC and MC) when compared with PMC, benign lesions and NT (P < 0.0001). LVD was higher in PC and PMC (P=0.001), and VEGF-C expression was increased in PC (P < 0.0001). Despite higher LVD and increased expression of VEGF-A and VEGF-C in thyroid cancers, these markers were not related to poor prognosis in terms of tumour size, multifocality and/or presence of lymphatic or distant metastases. In conclusion, angiogenesis is reduced in thyroid proliferative lesions compared with NT tissue. However, VEGF-A expression is upregulated in thyroid cancers. Lymphangiogenesis and VEGF-C expression are increased in thyroid tumours prone to lymphatic metastases. This may be an important mechanism underlying the differences in metastatic behaviour between papillary and follicular thyroid cancer.
引用
收藏
页码:931 / 944
页数:14
相关论文
共 46 条
[1]   Increased angiogenesis in papillary thyroid carcinoma but lack of prognostic importance [J].
Akslen, LA ;
LiVolsi, VA .
HUMAN PATHOLOGY, 2000, 31 (04) :439-442
[2]   Angiogenesis in human normal and pathologic adrenal cortex [J].
Bernini, GP ;
Moretti, A ;
Bonadio, AG ;
Menicagli, M ;
Viacava, P ;
Naccarato, AG ;
Iacconi, P ;
Miccoli, P ;
Salvetti, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (11) :4961-4965
[3]   Pituitary tumor transforming gene and fibroblast growth factor-2 expression: Potential prognostic indicators in differentiated thyroid cancer [J].
Boelaert, K ;
McCabe, CJ ;
Tannahill, LA ;
Gittoes, NJL ;
Holder, RL ;
Watkinson, JC ;
Bradwell, AR ;
Sheppard, MC ;
Franklyn, JA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (05) :2341-2347
[4]  
BREM SS, 1978, CANCER-AM CANCER SOC, V41, P239, DOI 10.1002/1097-0142(197801)41:1<239::AID-CNCR2820410133>3.0.CO
[5]  
2-X
[6]   Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features [J].
Bunone, G ;
Vigneri, P ;
Mariani, L ;
Butó, S ;
Collini, P ;
Pilotti, S ;
Pierotti, MA ;
Bongarzone, I .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (06) :1967-1976
[7]   TISSUE WEIGHTS AND RATES OF BLOOD FLOW IN MAN FOR PREDICTION OF ANESTHETIC UPTAKE AND DISTRIBUTION [J].
COWLES, AL ;
BORGSTEDT, HH ;
GILLIES, AJ .
ANESTHESIOLOGY, 1971, 35 (05) :523-+
[8]  
EGGO MC, 1995, J CLIN ENDOCR METAB, V80, P1006, DOI 10.1210/jc.80.3.1006
[9]   Vascular endothelial growth factor induces endothelial fenestrations in vitro [J].
Esser, S ;
Wolburg, K ;
Wolburg, H ;
Breier, G ;
Kurzchalia, T ;
Risau, W .
JOURNAL OF CELL BIOLOGY, 1998, 140 (04) :947-959
[10]   Vascular endothelial growth factor-C gene expression in papillary and follicular thyroid carcinomas [J].
Fellmer, PT ;
Sato, K ;
Tanaka, R ;
Okamoto, T ;
Kato, Y ;
Kobayashi, M ;
Shibuya, M ;
Obara, T .
SURGERY, 1999, 126 (06) :1056-1061