共 45 条
The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks
被引:281
作者:

Loizou, JI
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

El-Khamisy, SF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

Zlatanou, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

Moore, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

Chan, DW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

Qin, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

Sarno, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

论文数: 引用数:
h-index:
机构:

Pinna, LA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

Caldecott, KW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
机构:
[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
[2] Baylor Coll Med, Houston, TX 77030 USA
[3] Univ Padua, I-35121 Padua, Italy
[4] Venetian Inst Mol Med, I-35129 Padua, Italy
来源:
基金:
英国医学研究理事会;
关键词:
D O I:
10.1016/S0092-8674(04)00206-5
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
CK2 was the first protein kinase identified and is required for the proliferation and survival of mammalian cells. Here, we have identified an unanticipated role for CK2. We show that this essential protein kinase phosphorylates the scaffold protein XRCC1 and thereby enables the assembly and activity of DNA single-strand break repair protein complexes in vitro and at sites of chromosomal breakage. Moreover, we show that inhibiting XRCC1 phosphorylation by mutation of the CK2 phosphorylation sites or preventing CK2 activity using a highly specific inhibitor ablates the rapid repair of cellular DNA single-strand breaks by XRCC1. These data identify a direct role for CK2 in the repair of chromosomal DNA strand breaks and in maintaining genetic integrity.
引用
收藏
页码:17 / 28
页数:12
相关论文
共 45 条
[1]
Joining the cell survival squad: an emerging role for protein kinase CK2
[J].
Ahmed, K
;
Gerber, DA
;
Cochet, C
.
TRENDS IN CELL BIOLOGY,
2002, 12 (05)
:226-230

Ahmed, K
论文数: 0 引用数: 0
h-index: 0
机构:
CEA, INSERM EMI 0104, Dept Mol & Struct Biol, F-38054 Grenoble, France CEA, INSERM EMI 0104, Dept Mol & Struct Biol, F-38054 Grenoble, France

Gerber, DA
论文数: 0 引用数: 0
h-index: 0
机构: CEA, INSERM EMI 0104, Dept Mol & Struct Biol, F-38054 Grenoble, France

Cochet, C
论文数: 0 引用数: 0
h-index: 0
机构: CEA, INSERM EMI 0104, Dept Mol & Struct Biol, F-38054 Grenoble, France
[2]
Genome-wide expression screens indicate a global role for protein kinase CK2 in chromatin remodeling
[J].
Barz, T
;
Ackermann, K
;
Dubois, G
;
Eils, R
;
Pyerin, W
.
JOURNAL OF CELL SCIENCE,
2003, 116 (08)
:1563-1577

Barz, T
论文数: 0 引用数: 0
h-index: 0
机构:
Deutsch Krebsforschungszentrum, Biochem Zellphysiol B0200 & Intelligente Bioinfo, D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum, Biochem Zellphysiol B0200 & Intelligente Bioinfo, D-69120 Heidelberg, Germany

Ackermann, K
论文数: 0 引用数: 0
h-index: 0
机构:
Deutsch Krebsforschungszentrum, Biochem Zellphysiol B0200 & Intelligente Bioinfo, D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum, Biochem Zellphysiol B0200 & Intelligente Bioinfo, D-69120 Heidelberg, Germany

Dubois, G
论文数: 0 引用数: 0
h-index: 0
机构:
Deutsch Krebsforschungszentrum, Biochem Zellphysiol B0200 & Intelligente Bioinfo, D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum, Biochem Zellphysiol B0200 & Intelligente Bioinfo, D-69120 Heidelberg, Germany

Eils, R
论文数: 0 引用数: 0
h-index: 0
机构:
Deutsch Krebsforschungszentrum, Biochem Zellphysiol B0200 & Intelligente Bioinfo, D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum, Biochem Zellphysiol B0200 & Intelligente Bioinfo, D-69120 Heidelberg, Germany

Pyerin, W
论文数: 0 引用数: 0
h-index: 0
机构:
Deutsch Krebsforschungszentrum, Biochem Zellphysiol B0200 & Intelligente Bioinfo, D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum, Biochem Zellphysiol B0200 & Intelligente Bioinfo, D-69120 Heidelberg, Germany
[3]
Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole
[J].
Battistutta, R
;
De Moliner, E
;
Sarno, S
;
Zanotti, G
;
Pinna, LA
.
PROTEIN SCIENCE,
2001, 10 (11)
:2200-2206

Battistutta, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Dept Biol Chem, I-35121 Padua, Italy

De Moliner, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Dept Biol Chem, I-35121 Padua, Italy

Sarno, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Dept Biol Chem, I-35121 Padua, Italy

Zanotti, G
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Padua, Dept Biol Chem, I-35121 Padua, Italy Univ Padua, Dept Biol Chem, I-35121 Padua, Italy

Pinna, LA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Dept Biol Chem, I-35121 Padua, Italy
[4]
Disruption of the regulatory β subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality
[J].
Buchou, T
;
Vernet, M
;
Blond, O
;
Jensen, HH
;
Pointu, H
;
Olsen, BB
;
Cochet, C
;
Issinger, OG
;
Boldyreff, B
.
MOLECULAR AND CELLULAR BIOLOGY,
2003, 23 (03)
:908-915

Buchou, T
论文数: 0 引用数: 0
h-index: 0
机构: CEA Grenoble, DRDC, TS,INSERM, EMI10104, F-38054 Grenoble, France

Vernet, M
论文数: 0 引用数: 0
h-index: 0
机构: CEA Grenoble, DRDC, TS,INSERM, EMI10104, F-38054 Grenoble, France

Blond, O
论文数: 0 引用数: 0
h-index: 0
机构: CEA Grenoble, DRDC, TS,INSERM, EMI10104, F-38054 Grenoble, France

Jensen, HH
论文数: 0 引用数: 0
h-index: 0
机构: CEA Grenoble, DRDC, TS,INSERM, EMI10104, F-38054 Grenoble, France

Pointu, H
论文数: 0 引用数: 0
h-index: 0
机构: CEA Grenoble, DRDC, TS,INSERM, EMI10104, F-38054 Grenoble, France

Olsen, BB
论文数: 0 引用数: 0
h-index: 0
机构: CEA Grenoble, DRDC, TS,INSERM, EMI10104, F-38054 Grenoble, France

Cochet, C
论文数: 0 引用数: 0
h-index: 0
机构: CEA Grenoble, DRDC, TS,INSERM, EMI10104, F-38054 Grenoble, France

Issinger, OG
论文数: 0 引用数: 0
h-index: 0
机构: CEA Grenoble, DRDC, TS,INSERM, EMI10104, F-38054 Grenoble, France

Boldyreff, B
论文数: 0 引用数: 0
h-index: 0
机构: CEA Grenoble, DRDC, TS,INSERM, EMI10104, F-38054 Grenoble, France
[5]
XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly(ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro
[J].
Caldecott, KW
;
Aoufouchi, S
;
Johnson, P
;
Shall, S
.
NUCLEIC ACIDS RESEARCH,
1996, 24 (22)
:4387-4394

Caldecott, KW
论文数: 0 引用数: 0
h-index: 0
机构: MRC,MOL BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

Aoufouchi, S
论文数: 0 引用数: 0
h-index: 0
机构: MRC,MOL BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

Johnson, P
论文数: 0 引用数: 0
h-index: 0
机构: MRC,MOL BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

Shall, S
论文数: 0 引用数: 0
h-index: 0
机构: MRC,MOL BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
[6]
Mammalian DNA single-strand break repair: an X-ra(y)ted affair
[J].
Caldecott, KW
.
BIOESSAYS,
2001, 23 (05)
:447-455

Caldecott, KW
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
[7]
AN INTERACTION BETWEEN THE MAMMALIAN DNA-REPAIR PROTEIN XRCC1 AND DNA LIGASE-III
[J].
CALDECOTT, KW
;
MCKEOWN, CK
;
TUCKER, JD
;
LJUNGQUIST, S
;
THOMPSON, LH
.
MOLECULAR AND CELLULAR BIOLOGY,
1994, 14 (01)
:68-76

CALDECOTT, KW
论文数: 0 引用数: 0
h-index: 0
机构: LAWRENCE LIVERMORE NATL LAB,BIOL & BIOTECHNOL RES PROGRAM,POB 808,LIVERMORE,CA 94551

MCKEOWN, CK
论文数: 0 引用数: 0
h-index: 0
机构: LAWRENCE LIVERMORE NATL LAB,BIOL & BIOTECHNOL RES PROGRAM,POB 808,LIVERMORE,CA 94551

TUCKER, JD
论文数: 0 引用数: 0
h-index: 0
机构: LAWRENCE LIVERMORE NATL LAB,BIOL & BIOTECHNOL RES PROGRAM,POB 808,LIVERMORE,CA 94551

LJUNGQUIST, S
论文数: 0 引用数: 0
h-index: 0
机构: LAWRENCE LIVERMORE NATL LAB,BIOL & BIOTECHNOL RES PROGRAM,POB 808,LIVERMORE,CA 94551

THOMPSON, LH
论文数: 0 引用数: 0
h-index: 0
机构: LAWRENCE LIVERMORE NATL LAB,BIOL & BIOTECHNOL RES PROGRAM,POB 808,LIVERMORE,CA 94551
[8]
Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8
[J].
Desagher, S
;
Osen-Sand, A
;
Montessuit, S
;
Magnenat, E
;
Vilbois, F
;
Hochmann, A
;
Journot, L
;
Antonsson, B
;
Martinou, JC
.
MOLECULAR CELL,
2001, 8 (03)
:601-611

Desagher, S
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UPR 9023, Montpellier, France CNRS, UPR 9023, Montpellier, France

Osen-Sand, A
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, UPR 9023, Montpellier, France

Montessuit, S
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, UPR 9023, Montpellier, France

Magnenat, E
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, UPR 9023, Montpellier, France

Vilbois, F
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, UPR 9023, Montpellier, France

Hochmann, A
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, UPR 9023, Montpellier, France

Journot, L
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, UPR 9023, Montpellier, France

Antonsson, B
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, UPR 9023, Montpellier, France

Martinou, JC
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, UPR 9023, Montpellier, France
[9]
The FHA domain is a modular phosphopeptide recognition motif
[J].
Durocher, D
;
Henckel, J
;
Fersht, AR
;
Jackson, SP
.
MOLECULAR CELL,
1999, 4 (03)
:387-394

Durocher, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Wellcome Trust & Canc Res Campaign, Inst Canc & Dev Biol, Cambridge CB2 1QR, England

Henckel, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Wellcome Trust & Canc Res Campaign, Inst Canc & Dev Biol, Cambridge CB2 1QR, England

Fersht, AR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Wellcome Trust & Canc Res Campaign, Inst Canc & Dev Biol, Cambridge CB2 1QR, England

Jackson, SP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Wellcome Trust & Canc Res Campaign, Inst Canc & Dev Biol, Cambridge CB2 1QR, England
[10]
The molecular basis of FHA Domain:Phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms
[J].
Durocher, D
;
Taylor, IA
;
Sarbassova, D
;
Haire, LF
;
Westcott, SL
;
Jackson, SP
;
Smerdon, SJ
;
Yaffe, MB
.
MOLECULAR CELL,
2000, 6 (05)
:1169-1182

Durocher, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Wellcome Trust Canc Res Campaign Inst Can & Dev B, Cambridge CB2 1QR, England

Taylor, IA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Wellcome Trust Canc Res Campaign Inst Can & Dev B, Cambridge CB2 1QR, England

Sarbassova, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Wellcome Trust Canc Res Campaign Inst Can & Dev B, Cambridge CB2 1QR, England

Haire, LF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Wellcome Trust Canc Res Campaign Inst Can & Dev B, Cambridge CB2 1QR, England

Westcott, SL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Wellcome Trust Canc Res Campaign Inst Can & Dev B, Cambridge CB2 1QR, England

论文数: 引用数:
h-index:
机构:

Smerdon, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Wellcome Trust Canc Res Campaign Inst Can & Dev B, Cambridge CB2 1QR, England

Yaffe, MB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Wellcome Trust Canc Res Campaign Inst Can & Dev B, Cambridge CB2 1QR, England