Aldosterone: Refreshing a slow hormone by swift action

被引:18
作者
Boldyreff, B [1 ]
Wehling, M [1 ]
机构
[1] Heidelberg Univ, Fac Clin Med Mannheim, Dept Clin Pharmacol, D-68167 Mannheim, Germany
来源
NEWS IN PHYSIOLOGICAL SCIENCES | 2004年 / 19卷
关键词
D O I
10.1152/nips.01596.2003
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Aldosterone elicits not only genomic effects with physiological consequences within hours or days but also elicits rapid nongenomic effects, such as activation of sodium transport in target cells, within seconds or minutes. Rapid aldosterone effects, which have also, been shown in several in vivo studies in humans (e.g., increase in peripheral vascular resistance and blood pressure), are of potential clinical importance.
引用
收藏
页码:97 / 100
页数:4
相关论文
共 20 条
[1]   Rapid aldosterone actions: from the membrane to signaling cascades to gene transcription and physiological effects [J].
Boldyreff, B ;
Wehling, M .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2003, 85 (2-5) :375-381
[2]   Rapid actions of aldosterone: lymphocytes, vascular smooth muscle and endothelial cells [J].
Christ, M ;
Wehling, M .
STEROIDS, 1999, 64 (1-2) :35-41
[3]   Hypoxia modulates rapid effects of aldosterone on oxidative metabolism in human calf muscle [J].
Christ, M ;
Zange, J ;
Janson, CP ;
Müller, K ;
Kuklinski, P ;
Schmidt, BMW ;
Tillmann, HC ;
Gerzer, R ;
Wehling, M .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2001, 24 (08) :587-597
[4]   Rapid effects of steroid hormones on free intracellular calcium in T84 colonic epithelial cells [J].
Doolan, CM ;
Harvey, BJ .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1996, 271 (06) :C1935-C1941
[5]  
EISEN C, 1994, CELL MOL BIOL, V40, P351
[6]   Specific progesterone binding to a membrane protein and related nongenomic effects on Ca2+-fluxes in sperm [J].
Falkenstein, E ;
Heck, M ;
Gerdes, D ;
Grube, D ;
Christ, M ;
Weigel, M ;
Buddhikot, M ;
Meizel, S ;
Wehling, M .
ENDOCRINOLOGY, 1999, 140 (12) :5999-6002
[7]   Rapid activation of Na+/H+-exchange in MDCK cells by aldosterone involves MAP-kinases ERK 1/2 [J].
Gekle, M ;
Freudinger, R ;
Mildenberger, S ;
Schenk, K ;
Marschitz, I ;
Schramek, H .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2001, 441 (06) :781-786
[8]   Rapid activation of Na+/H+ exchange by aldosterone in renal epithelial cells requires Ca2+ and stimulation of a plasma membrane proton conductance [J].
Gekle, M ;
Golenhofen, N ;
Oberleithner, H ;
Silbernagl, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) :10500-10504
[9]   Human epidermal growth factor receptor-1 expression renders chinese hamster ovary cells sensitive to alternative aldosterone signaling [J].
Krug, AW ;
Schuster, C ;
Gassner, B ;
Freudinger, R ;
Mildenberger, S ;
Troppmair, J ;
Gekle, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (48) :45892-45897
[10]   Cellular functions of plasma membrane estrogen receptors [J].
Levin, ER .
STEROIDS, 2002, 67 (06) :471-475