The 2010 boreal summer marked a worldwide abnormal climate. An unprecedented heat wave struck East Asia in July and August 2010. In addition to this, the tropical Indian Ocean was abnormally warm during the summer of 2010. Several heavy rainfall events and associated floods were also reported in the Indian monsoon region. During the season, the monsoon trough (an east-west elongated area of low pressure) was mostly located south of its normal position and monsoon low pressure systems moved south of their normal tracks. This resulted in an uneven spatial distribution with above-normal rainfall over peninsular and Northwest India, and deficient rainfall over central and northeastern parts of India, thus prediction (and simulation) of such anomalous climatic summer season is important. In this context, evolution of vertical moist thermodynamic structure associated with Indian summer monsoon 2010 is studied using regional climate model, reanalysis and satellite observations. This synergised approach is the first of its kind to the best of our knowledge. The model-simulated fields (pressure, temperature, winds and precipitation) are comparable with the respective in situ and reanalysis fields, both in intensity and geographical distribution. The correlation coefficient between model and observed precipitation is 0.5 and the root-mean-square error (RMSE) is 4.8 mm day(-1). Inter-comparison of model-simulated fields with satellite observations reveals that the midtropospheric temperature [Water vapour mixing ratio (WVMR)] has RMSE of 0.5 K (1.6 g kg(-1)), whereas the surface temperature (WVMR) has RMSE of 3.4 K (2.2 g kg(-1)). Similarly, temporal evolution of vertical structure of temperature with rainfall over central Indian region reveals that the baroclinic nature of monsoon is simulated by the model. The midtropospheric warming associated with rainfall is captured by the model, whereas the model failed to capture the surface response to high and low rainfall events. The model has strong water vapour loading in the whole troposphere, but weaker coherent response with rainfall compared to observations. Thus, strong water vapour loading and overestimation of rainfall are reported in the model. This study put forward that the discrepancy in the model-simulated structure may be reduced by assimilation of satellite observations.