Pathogen recognition by innate immunity and its signaling

被引：191

作者：

Akira, Shizuo ^{[1
]}

机构：

[1] Osaka Univ, Host Def Lab, WPI Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 2009年 / 85卷 / 04期

关键词：

Toll-like receptor; innate immunity; pathogen; interferon; signaling; cytokine; NF-KAPPA-B; DOUBLE-STRANDED-RNA; DOMAIN-CONTAINING ADAPTER; IFN-REGULATORY FACTOR-3; TANK-BINDING KINASE-1; RIG-I; CUTTING EDGE; TRANSCRIPTION FACTORS; DIFFERENTIAL ROLES; ACTIVATION;

D O I：

10.2183/pjab.85.143

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mammalian immune response can be divided into innate and acquired immunity. Furthermore, much evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity. This paradigm shift has changed our thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.

引用

页码：143 / 156

页数：14

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