Actions of Quercetin, a Polyphenol, on Blood Pressure

被引：181

作者：

Marunaka, Yoshinori ^{[1
,2
,3
]}

Marunaka, Rie ^{[1
,4
]}

Sun, Hongxin ^{[1
]}

Yamamoto, Toshiro ^{[4
]}

Kanamura, Narisato ^{[4
]}

Inui, Toshio ^{[1
,2
,5
]}

Taruno, Akiyuki ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Mol Cell Physiol, Kyoto 6028566, Japan

[2] Kyoto Prefectural Univ Med, Dept Bioion, Kyoto 6028566, Japan

[3] St Agnes Univ, Japan Inst Food Educ & Hlth, Kyoto 6028013, Japan

[4] Kyoto Prefectural Univ Med, Dept Dent Med, Kyoto 6028566, Japan

[5] Saisei Mirai Clin, Moriguchi, Osaka 5700012, Japan

来源：

MOLECULES | 2017年 / 22卷 / 02期

关键词：

flavonoid; quercetin; Na+-K+-2Cl(-) cotransporter 1; epithelial Na+ channel; cytosolic Cl- concentration; EPITHELIAL NA+ CHANNEL; LIDDLES-SYNDROME; FLAVONOID QUERCETIN; OXIDATIVE STATUS; ENAC EXPRESSION; NEURONAL CELL; NITRIC-OXIDE; SODIUM; ANTIOXIDANT; SECRETION;

D O I：

10.3390/molecules22020209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Disorder of blood pressure control causes serious diseases in the cardiovascular system. This review focuses on the anti-hypertensive action of quercetin, a flavonoid, which is one of the polyphenols characterized as the compounds containing large multiples of phenol structural units, by varying the values of various blood pressure regulatory factors, such as vascular compliance, peripheral vascular resistance, and total blood volume via anti-inflammatory and anti-oxidant actions. In addition to the anti-inflammatory and anti-oxidant actions of quercetin, we especially describe a novel mechanism of quercetin's action on the cytosolic Cl- concentration ([Cl-](c)) and novel roles of the cytosolic Cl- i.e., (1) quercetin elevates [Cl-](c) by activating Na+-K+-2Cl(-) cotransporter 1 (NKCC1) in renal epithelial cells contributing to Na+ reabsorption via the epithelial Na+ channel (ENaC); (2) the quercetin-induced elevation of [Cl-](c) in renal epithelial cells diminishes expression of ENaC leading to a decrease in renal Na+ reabsorption; and (3) this reduction of ENaC-mediated Na+ reabsorption in renal epithelial cells drops volume-dependent elevated blood pressure. In this review, we introduce novel, unique mechanisms of quercetin's anti-hypertensive action via activation of NKCC1 in detail.

引用

页数：12

共 82 条

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