The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke

被引：85

作者：

Sutherland, Brad A. ^{[1
]}

Neuhaus, Ain A. ^{[1
]}

Couch, Yvonne ^{[1
]}

Balami, Joyce S. ^{[2
,3
]}

DeLuca, Gabriele C. ^{[4
]}

Hadley, Gina ^{[1
]}

Harris, Scarlett L. ^{[1
]}

Grey, Adam N. ^{[1
]}

Buchan, Alastair M. ^{[1
]}

机构：

[1] Univ Oxford, Radcliffe Dept Med, Acute Stroke Programme, Oxford OX3 9DU, England

[2] Univ Oxford, Ctr Evidence Based Med, Oxford OX3 9DU, England

[3] Norfolk & Norwich Univ Teaching Hosp NHS Trust, Norwich, Norfolk, England

[4] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2016年 / 36卷 / 02期

基金：

英国医学研究理事会;

关键词：

Ischemic stroke; middle cerebral artery occlusion; endovascular thrombectomy; cerebral blood flow; animal models; ACUTE ISCHEMIC-STROKE; INTRAVENOUS T-PA; BRAIN ISCHEMIA; IMAGING SELECTION; RANDOMIZED-TRIAL; REPERFUSION; THERAPY; RATS; INFARCTION; INJURY;

D O I：

10.1177/0271678X15606722

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The clinical relevance of the transient intraluminal filament model of middle cerebral artery occlusion (tMCAO) has been questioned due to distinct cerebral blood flow profiles upon reperfusion between tMCAO (abrupt reperfusion) and alteplase treatment (gradual reperfusion), resulting in differing pathophysiologies. Positive results from recent endovascular thrombectomy trials, where the occluding clot is mechanically removed, could revolutionize stroke treatment. The rapid cerebral blood flow restoration in both tMCAO and endovascular thrombectomy provides clinical relevance for this pre-clinical model. Any future clinical trials of neuroprotective agents as adjuncts to endovascular thrombectomy should consider tMCAO as the model of choice to determine pre-clinical efficacy.

引用

页码：363 / 369

页数：7

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