Efficacy and safety of Etanercept, high-dose intravenous gammaglobulin and plasmapheresis combined therapy for lupus diffuse proliferative nephritis complicating pregnancy

被引：35

作者：

Micheloud, D.

Nuno, L.

Rodriguez-Mahou, M.

Sanchez-Ramon, S.

Ortega, M. C.

Aguaron, A.

Junco, E.

Carbone, J.

Fernandez-Cruz, E.

Carreno, L.

Lopez-Longo, F. J.

机构：

[1] Univ Gen Hosp Gregorio Maranon, Dept Reumatol, Madrid 28007, Spain

[2] Univ Gen Hosp Gregorio Maranon, Dept Immunol, Madrid 28007, Spain

[3] Univ Gen Hosp Gregorio Maranon, Dept Gynecol & Obstet, Madrid 28007, Spain

[4] Univ Gen Hosp Gregorio Maranon, Dept Nephrol, Madrid 28007, Spain

来源：

LUPUS | 2006年 / 15卷 / 12期

关键词：

systemic lupus erytematosus; pregnancy; etanercept; intravenous gammaglobulin and plasmapheresis;

D O I：

10.1177/0961203306070970

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report one case of pregnancy-onset severe diffuse proliferative nephritis in a patient with systemic lupus erythematosus (SLE), who was successfully treated with a combination of anti-tumour necrosis factor (TNF)-alpha, plasmapheresis and high-dose intravenous gammaglobulin. No flares were observed either in clinical symptoms or in laboratory examinations during pregnancy or after delivery. Her autoantibodies except fluorescent anti-nuclear antibodies were negative. We suggest that a combination of anti-TNF-alpha, plasmapheresis and high-dose intravenous gammaglobulin may be a safe and effective therapy for pregnant patients suffering severe lupus nephritis.

引用

收藏

页码：881 / 885

页数：5

相关论文

共 40 条

[1] Successful treatment of rapidly progressive lupus nephritis associated with anti-MPO antibodies by intravenous immunoglobulins [J].

Arahata, H ;

Migita, K ;

Izumoto, H ;

Miyashita, T ;

Munakata, H ;

Nakamura, H ;

Tominaga, M ;

Origuchi, T ;

Kawabe, Y ;

Hida, A ;

Taguchi, T ;

Eguchi, K .

CLINICAL RHEUMATOLOGY, 1999, 18 (01) :77-81

[2] Safety and efficacy of tumor necrosis factor α blockade in systemic lupus erythematosus -: An open-label study [J].

Aringer, M ;

Graninger, WB ;

Steiner, GN ;

Smolen, JS .

ARTHRITIS AND RHEUMATISM, 2004, 50 (10) :3161-3169

[3] Intravenous immunoglobulin compared with cyclophosphamide for proliferative lupus nephritis [J].

Boletis, JN ;

Ioannidis, JPA ;

Boki, KA ;

Moutsopoulos, HM .

LANCET, 1999, 354 (9178) :569-570

[4]

CARRENO L, 2005, THERAPEUTICAL APHERE, P102

[5]

Carreno Luis, 2002, Paediatr Drugs, V4, P241, DOI 10.2165/00148581-200204040-00004

[6] Morbidity and mortality in systemic lupus erythematosus during a 10-year period -: A comparison of early and late manifestations in a cohort of 1,000 patients [J].

Cervera, R ;

Khamashta, MA ;

Font, J ;

Sebastiani, GD ;

Gil, A ;

Lavilla, P ;

Mejía, JC ;

Aydintug, AC ;

Chwalinska-Sadowska, H ;

de Ramón, E ;

Fernández-Nebro, A ;

Galeazzi, M ;

Valen, M ;

Mathieu, A ;

Houssiau, FD ;

Caro, N ;

Alba, P ;

Ramos-Casals, M ;

Ingelmo, M ;

Hughes, GRV .

MEDICINE, 2003, 82 (05) :299-308

[7] Clinical predictors of fetal and maternal outcome in systemic lupus erythematosus:: a prospective study of 103 pregnancies [J].

Cortés-Hernández, J ;

Ordi-Ros, J ;

Paredes, F ;

Casellas, M ;

Castillo, F ;

Vilardell-Tarres, M .

RHEUMATOLOGY, 2002, 41 (06) :643-650

[8] Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia [J].

Dechend, R ;

Gratze, P ;

Wallukat, G ;

Shagdarsuren, E ;

Plehm, R ;

Bräsen, JH ;

Fiebeler, A ;

Schneider, W ;

Caluwaerts, S ;

Vercruysse, L ;

Pijnenborg, R ;

Luft, FC ;

Müller, DN .

HYPERTENSION, 2005, 45 (04) :742-746

[9] Activating auto-antibodies against the AT1 receptor in preeclampsia [J].

Dechend, R ;

Müller, DN ;

Wallukat, G ;

Homuth, V ;

Krause, M ;

Dudenhausen, J ;

Luft, FC .

AUTOIMMUNITY REVIEWS, 2005, 4 (01) :61-65

[10] Intravenous immunoglobulin therapy is not able to efficiently control cutaneous manifestations in patients with lupus erythematosus [J].

DePita, O ;

Bellucci, AM ;

Ruffelli, M ;

Girardelli, CR ;

Puddu, P .

LUPUS, 1997, 6 (04) :415-417

← 1 2 3 4 →