Thermodynamic and structural properties of Gd(III) complexes with polyamino-polycarboxylic ligands: basic compounds for the development of MRI contrast agents

被引：162

作者：

Bianchi, A

Calabi, L

Corana, F

Fontana, S

Losi, P

Maiocchi, A

Paleari, L

Valtancoli, B

机构：

[1] Univ Florence, Dept Chem, I-50144 Florence, Italy

[2] Bracco SpA, Milano Res Ctr, I-20134 Milan, Italy

来源：

COORDINATION CHEMISTRY REVIEWS | 2000年 / 204卷

关键词：

gadolinium; contrast agents; imaging; lanthanides; complexation thermodynamics;

D O I：

10.1016/S0010-8545(99)00237-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The main purpose of this review is to collect equilibrium data in aqueous solution and structural properties in the solid state for significant examples of Gd(III) complexes with both acyclic and macrocyclic polyamino-polycarboxylic ligands. The intent is to determine the ligand characteristics which contribute to the complexes' stability. Several aspects connected with the use of similar Gd(III) complexes as contrast agents in nuclear magnetic resonance imaging are also considered. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：309 / 393

页数：85

共 141 条

[1] SYNTHESIS, CHARACTERIZATION, AND 1/T(1) NMRD PROFILES OF GADOLINIUM(III) COMPLEXES OF MONOAMIDE DERIVATIVES OF DOTA-LIKE LIGANDS - X-RAY STRUCTURE OF THE 10-[2-[[2-HYDROXY-1-(HYDROXYMETHYL)ETHYL]AMINO]-1-[(PHENYLMETHOXY)METHYL]-2-OXO-ETHYL]-1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC ACID GADOLINIUM(III) COMPLEX [J].