Reductive generation of enolates from enones using elemental hydrogen: Catalytic C-C bond formation under hydrogenative conditions

被引：110

作者：

Jang, HY ^{[1
]}

Huddleston, RR ^{[1
]}

Krische, MJ ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 51期

关键词：

D O I：

10.1021/ja021163l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Exposure of enones to elemental hydrogen in the presence of a Rh(I) catalyst enables reductive enolate generation, as evidenced by electrophilic trapping of the enolate by appendant and exogenous aldehyde partners. The significance of these findings resides in the ability to regioselectivity generate and transform transition metal enolates under catalytic conditions that circumvent formation of stoichiometric byproducts. Copyright © 2002 American Chemical Society.

引用

页码：15156 / 15157

页数：2

共 28 条

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[Anonymous], 1984, ASYMMETRIC SYNTHESIS

[2] Asymmetric conjugate reduction of α,β-unsaturated esters using a chiral phosphine-copper catalyst [J].