Metabolic consideration of epiphyseal growth: Survival responses in a taxing environment

被引：20

作者：

Shapiro, Irving M. ^{[1
]}

Srinivas, Vickram ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Orthopaed Surg, Philadelphia, PA 19104 USA

来源：

BONE | 2007年 / 40卷 / 03期

关键词：

chondrocyte; epiphyseal growth plate; metabolism; oxygen; HIF; PHD; mTOR; akt; AMPK;

D O I：

10.1016/j.bone.2006.09.030

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The goal of this review is to examine some of the metabolic features of the maturing chondrocyte within the epiphyseal growth plate. The energy status of the tissue is examined in light of the energy needs of the tissue and the availability of oxygen. The role of HIF, PHDs and other proteins concerned with transduction of the oxemic response is considered and related to chondrocyte survival in a complex extracellular matrix. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：561 / 567

页数：7

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