Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer

被引：304

作者：

Neumueller, Ralph A. ^{[1
]}

Knoblich, Juergen A. ^{[1
]}

机构：

[1] Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 23期

基金：

奥地利科学基金会;

关键词：

Asymmetric cell division; cell polarity; neurogenesis; stem cell; tumorigenesis; C-ELEGANS EMBRYOS; HETEROTRIMERIC G-PROTEINS; NEUROBLAST SELF-RENEWAL; CENTRAL-NERVOUS-SYSTEM; REGULATES SPINDLE ORIENTATION; IMMORTAL STRAND HYPOTHESIS; SENSORY ORGAN PRECURSORS; RIBOSOMAL-RNA SYNTHESIS; ACUTE MYELOID-LEUKEMIA; DROSOPHILA OPTIC LOBE;

D O I：

10.1101/gad.1850809

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell division is commonly thought to involve the equal distribution of cellular components into the two daughter cells. During many cell divisions, however, proteins, membrane compartments, organelles, or even DNA are asymmetrically distributed between the two daughter cells. Here, we review the various types of asymmetries that have been described in yeast and in animal cells. Asymmetric segregation of protein determinants is particularly relevant for stem cell biology. We summarize the relevance of asymmetric cell divisions in various stem cell systems and discuss why defects in asymmetric cell division can lead to the formation of tumors.

引用

页码：2675 / 2699

页数：25

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