Associative learning disrupted by impaired G(s) signaling in Drosophila mushroom bodies

被引:407
作者
Connolly, JB
Roberts, IJH
Armstrong, JD
Kaiser, K
Forte, M
Tully, T
OKane, CJ
机构
[1] UNIV CAMBRIDGE,DEPT GENET,CAMBRIDGE CB2 3EH,ENGLAND
[2] UNIV GLASGOW,INST BIOMED & LIFE SCI,DIV MOL GENET,GLASGOW G11 6NU,LANARK,SCOTLAND
[3] OREGON HLTH SCI UNIV,VOLLUM INST ADV BIOMED RES,PORTLAND,OR 97201
基金
英国惠康基金;
关键词
D O I
10.1126/science.274.5295.2104
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Disruptions in mushroom body (MB) or central complex (CC) brain structures impair Drosophila associative olfactory learning. Perturbations in adenosine 3',5' monophosphate signaling also disrupt learning. To integrate these observations, expression of a constitutively activated stimulatory heterotrimeric guanosine triphosphate-binding protein alpha subunit (G alpha(s)(star)) was targeted to these brain structures. The ability to associate odors with electroshock was abolished when G alpha(s)(star) was targeted to MB, but not CC, structures, whereas sensorimotor responses to these stimuli remained normal, Expression of G alpha(s)(star) did not affect gross MB morphology, and wild-type G alpha(s) expression did not affect learning, Thus, olfactory learning depends on regulated G(s) signaling in Drosophila MBs.
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页码:2104 / 2107
页数:4
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