Cadherin-11 in synovial lining formation and pathology in arthritis

被引：317

作者：

Lee, David M.

Kiener, Hans P.

Agarwal, Sandeep K.

Noss, Erika H.

Watts, Gerald F. M.

Chisaka, Osamu

Takeichi, Masatoshi

Brenner, Michael B.

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA

[3] Kyoto Univ, Dept Cell & Dev Biol, Grad Sch Biostudies, Sakyo Ku, Kyoto 6068501, Japan

[4] RIKEN, Ctr Dev Biol, Chuo Ku, Kobe, Hyogo 6500047, Japan

来源：

SCIENCE | 2007年 / 315卷 / 5814期

关键词：

D O I：

10.1126/science.1137306

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The normal synovium forms a membrane at the edges of joints and provides lubrication and nutrients for the cartilage. In rheumatoid arthritis, the synovium is the site of inflammation, and it participates in an organized tissue response that damages cartilage and bone. We identified cadherin-11 as essential for the development of the synovium. Cadherin-11-deficient mice have a hypoplastic synovial lining, display a disorganized synovial reaction to inflammation, and are resistant to inflammatory arthritis. Cadherin-11 therapeutics prevent and reduce arthritis in mouse models. Thus, synovial cadherin-11 determines the behavior of synovial cells in their proinflammatory and destructive tissue response in inflammatory arthritis.

引用

页码：1006 / 1010

页数：5

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