Comparison of several methods used for the determination of cephalosporins.: Analysis of cephalexin in pharmaceutical samples

被引：38

作者：

Martínez, LG ^{[1
]}

Falcó, PC ^{[1
]}

Cabeza, AS ^{[1
]}

机构：

[1] Univ Valencia, Fac Quim, Dept Quim, E-46100 Valencia, Spain

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 29卷 / 03期

关键词：

cephalosporins; ninhydrin; spectrophotometry; high performance liquid chromatography; H-point Standard Additions Method; pharmaceutical samples;

D O I：

10.1016/S0731-7085(02)00089-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The precision of UV absorbance of intac and acid degraded cephalosporins, ninhydrin, high performance liquid chromatography and iodometric methods used for analysis of cefoxitin, cefotaxime, cephazolin and cephalexin were compared. To obtain the calibration graphs the analytical signal used were: absorbance, first derivative absorbance, second derivative absorbance and H-point Standard Additions Method by using absorbance values at two selected wavelengths as analytical signal. These methods and calibration graphs were also used for the determination of cephalexin in pharmaceutical samples. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：405 / 423

页数：19

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