R2* magnetic resonance imaging of the liver in patients with iron overload

被引:300
作者
Hankins, Jane S. [1 ]
McCarville, M. Beth [2 ]
Loeffler, Ralf B. [2 ]
Smeltzer, Matthew P. [3 ]
Onciu, Mihaela [4 ]
Hoffer, Fredric A. [2 ]
Li, Chin-Shang [3 ]
Wang, Winfred C. [1 ]
Ware, Russell E. [1 ]
Hillenbrand, Claudia M. [2 ]
机构
[1] St Jude Childrens Res Hosp, Dept Hematol, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Radiol Sci, Memphis, TN 38105 USA
[3] St Jude Childrens Res Hosp, Dept Biostat, Memphis, TN 38105 USA
[4] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA
关键词
SICKLE-CELL-DISEASE; THALASSEMIA; STORES; MRI;
D O I
10.1182/blood-2008-12-191643
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Forty-three patients (sickle cell anemia, n = 32; beta-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (+/- SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P <.01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P <.001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038. (Blood. 2009;113:4853-4855)
引用
收藏
页码:4853 / 4855
页数:3
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